Примери за използване на Boosted with ritonavir на Английски и техните преводи на Български
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Tipranavir boosted with ritonavir.
Medicinal products that may be affected by darunavir boosted with ritonavir.
Lopinavir boosted with ritonavir+ emtricitabine/ tenofovir disoproxil fumarate.
Darunavir may therefore have different recommendations for concomitant medications depending on whether the compound is boosted with ritonavir or cobicistat.
Protease inhibitors boosted with ritonavir or cobicistat, boceprevir, telaprevir.
Pharmacokinetic enhancer andconcomitant medications Darunavir has different interaction profiles depending on whether the compound is boosted with ritonavir or cobicistat.
Darunavir boosted with ritonavir(800 mg/ 100 mg once daily)/ sofosbuvir(400 mg once daily).
Withdrawal of ritonavir only under restrictive conditions The recommended standard treatment is REYATAZ boosted with ritonavir, ensuring optimal pharmacokinetic parameters and level of virologic suppression.
Darunavir boosted with ritonavir(800 mg/ 100 mg once daily)/ ledipasvir(90 mg once daily)d.
The recommendations given for concomitant use of atazanavir andother medicinal products may, therefore, differ depending on whether atazanavir is boosted with ritonavir or cobicistat.
Clinical experience with fosamprenavir boosted with ritonavir is mainly based on three open label studies.
Darunavir boosted with ritonavir(800/ 100 mg once daily)+ emtricitabine/ tenofovir disoproxil fumarate(200/ 300 mg once daily)/ sofosbuvir/ velpatasvir(400/ 100 mg once daily)c, d.
Darunavir may therefore have different contraindications andrecommendations for concomitant medications depending on whether the compound is boosted with ritonavir see sections 4.3, 4.4 and.
The benefit of amprenavir boosted with ritonavir has not been demonstrated in PI naïve patients.
For co-administration with strong CYP3A4 inhibitors,the same recommendations apply independent of whether darunavir is boosted with ritonavir or with cobicistat(see section above).
The safety and activity of saquinavir boosted with ritonavir in HIV-infected patients less than 2 years have not been established.
For co-administration with strong CYP3A4 inhibitors,the same recommendations apply independent of whether darunavir is boosted with ritonavir or with cobicistat(see section above).
HIV ANTIVIRAL AGENTS: HIV PROTEASE INHIBITORS Atazanavir boosted with ritonavir(300+ 100 mg single dose)+ sofosbuvir/ velpatasvir/voxilaprevir(400/100/100 mg single dose)f.
In study GS-US-216-0114, the mean increase from baseline in CD4+ cell count at weeks 48 and 144 were 213 and 310 cells/mm3 in patients receiving atazanavir boosted with cobicistat and 219 and332 cells/mm3 in patients receiving atazanavir boosted with ritonavir, respectively.
HIV ANTIVIRAL AGENTS: HIV PROTEASE INHIBITORS Atazanavir boosted with ritonavir(300 mg/ 100 mg once daily)/ ledipasvir(90 mg once daily)c/ sofosbuvir(400 mg once daily)c, d.
In study GS-US-216-0114, through 144 weeks of treatment hyperbilirubinaemia(> 1 x ULN) was common: 97.7% in the atazanavir boosted with cobicistat plus emtricitabine andtenofovir DF fixed-dose combination group, and 97.4% in the atazanavir boosted with ritonavir plus emtricitabine and tenofovir DF fixed-dose combination group.
Darunavir boosted with ritonavir(800 mg/ 100 mg once daily)+ emtricitabine/ tenofovir disoproxil fumarate(200 mg/ 300 mg once daily)/ ledipasvir(90 mg once daily)c/ sofosbuvir(400 mg once daily)c, d.
Response rates were higher in APTIVUS/ ritonavir patients than comparator PI boosted with ritonavir in new enfuvirtide patients, or patients without new enfuvirtide.
Darunavir boosted with ritonavir(800+ 100 mg once daily)+ emtricitabine/ tenofovir disoproxil fumarate(200/300 mg once daily)j+ sofosbuvir/ velpatasvir/voxilaprevir(400/100/100 mg once daily)+ voxilaprevir(100 mg once daily)f.
Patients were on a stable ARV regimen(for at least 6 months),consisting of a boosted protease inhibitor[either darunavir once daily or atazanavir(both boosted with ritonavir or cobicistat), or lopinavir with ritonavir] combined with emtricitabine and TDF.
HIV ANTIVIRAL AGENTS: HIV PROTEASE INHIBITORS Atazanavir boosted with ritonavir(300/ 100 mg once daily)+ emtricitabine/ tenofovir disoproxil fumarate(200/ 300 mg once daily)/ sofosbuvir/ velpatasvir(400/ 100 mg once daily)c, d.
The mean(± SD) change in estimated glomerular filtration rate(eGFR) by Cockcroft-Gault method after 144 weeks of treatment was -15.1± 16.5 ml/min in the atazanavir boosted with cobicistat plusemtricitabine and tenofovir DF fixed-dose combination group and -8.0± 16.8 ml/min in the atazanavir boosted with ritonavir plus emtricitabine and tenofovir DF fixed-dose combination group.
Clinical experience with fosamprenavir boosted with ritonavir is mainly based on two open label studies, one in antiretroviral naïve patients(study ESS100732), and one study in antiretroviral experienced patients(study APV30003).
The recommendations shown in Table 1 are based on either drug interaction trials of unboosted atazanavir,atazanavir boosted with ritonavir, cobicistat or predicted interactions due to the expected magnitude of the interaction and potential for serious adverse reactions or loss of therapeutic effect of EVOTAZ.
Agenerase boosted with ritonavir must not be taken by patients who have severe problems with their liver, or by patients taking rifampicin(used to treat tuberculosis) or medicines that are broken down in the same way as ritonavir, such as flecainide and propafenone(used to correct irregular heartbeat).