白血病抑制因子leukemiainhibitoryfactor(LIF)是维持小鼠胚胎干细胞处于增殖、未分化状态所必需的一种生长因子。
Leukemia inhibitory factor(LIF)âAgrowth factor necessary for maintaining mouse embryonic stem cells in a proliferative, undifferentiated state.Saitou和他的同事从两种细胞类型开始,即小鼠胚胎干细胞和诱导多能干细胞,其可以来自成体细胞。
Saitou and his colleagues started with two cell types, mouse embryonic stem cells and induced pluripotent stem cells, which can be derived from adult cells..Tet1和Tet2规管5Hydroxymethylcytosine生产和单元格沿袭规范在小鼠胚胎干细胞。
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production andcell lineage specification in mouse embryonic stem cells.来自印第安那大学的科学家们成功地将小鼠胚胎干细胞转化成了内耳重要结构。
Indiana University scientists have transformed mouse embryonic stem cells into key structures of the inner ear.Combinations with other parts of speech
来自印第安那大学的科学家们成功地将小鼠胚胎干细胞转化成了内耳重要结构。
Scientists from Indiana University have transformed mouse embryonic stem cells into key structures of the inner ear.来自印第安那大学的科学家们成功地将小鼠胚胎干细胞转化成了内耳重要结构。
Indiana University scientists have used mouse embryonic stem cells to make key structures of the inner ear.进一步研究表明,tRNA-Gly-GCC抑制了一组基因的表达,其中一个基因涉及了小鼠胚胎干细胞的可塑性。
Data findings show that tRNA-Gly-GCC suppresses a subset of genes,including a gene that contributes to the plasticity of mouse embryonic stem cells.因此,这项新研究的研究人员研究了小鼠胚胎干细胞,试图了解干细胞如何抵抗病毒。
So the researchers on the new study examined stem cells from mouse embryos, trying to learn more about howstem cells resist viruses.当研究人员分析了小鼠胚胎干细胞中的15种核糖体蛋白时,他们发现,有9种在所有核糖体中同样常见。
When the researchers analyzed 15 ribosomal proteins in mouse embryonic stem cells, they found that nine of the proteins were equally commonin all ribosomes.到,SILAC标签和小鼠胚胎干细胞的蛋白质组定量至5111种蛋白质,细胞摩尔蛋白质组学的深度。
SILAC-labeling and proteome quantitation of mouse embryonic stem cells to a depth of 5111 proteins.Schorn仔细地分析了小鼠胚胎干细胞的内含物,发现很多自由漂浮的长18nt的RNA片段。
Schorn scrutinized the contents of mouse embryonic stem cells and found many free-floating RNA fragments 18 nucleotides in length.该技术可以让他们推断小鼠胚胎干细胞中的19000多种RNA分子结构,相关研究成果于今年年初发表。
This allowed them to deduce the structures of more than 19,000 RNAs in mouse embryonic stem cells, an effort they published earlier this year.此外,我们会泄露5fC和5caC在小鼠胚胎干细胞和鼠标器官的基因组DNA的存在。
Furthermore, we reveal the presence of 5fC and5caC in genomic DNA of mouse embryonic stem cells and mouse organs.Sox17促进小鼠胚胎干细胞分化胚外基因表达直接调控与间接对抗自我更新。
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.来自Hubrecht研究所(KNAW)和剑桥大学(英国)的科学家已经设法从小鼠胚胎干细胞中产生复杂的类胚胎结构。
Scientists from the Hubrecht Institute(KNAW) and the University of Cambridge(UK)have managed to generate complex embryo-like structures from mouse embryonic stem cells.Zhang研究组分析了Tet1在整个小鼠胚胎干细胞基因组中的存留时间。
Zhang's team analyzed Tet1's occupancy across the entire mouse embryonic stem cell genome.上世纪80年代,科学家们通过将小片段DNA添加到小鼠胚胎干细胞中,构建出了第一个转基因小鼠。
The first genetically altered mice were created in the1980s by adding small pieces of DNA to mouse embryonic cells.这个细胞库-称为Haplobank--包含超过100,000个突变的条件性小鼠胚胎干细胞系,靶向约70%的蛋白质编码基因组(近17,000个基因)。
This cell bank- called Haplobank- contains over 100,000 mutated,conditional mouse embryonic stem cell lines, targeting about 70% of the protein-coding genome.这种被称作Haplobank的细胞库含有10万多种突变的条件性的小鼠胚胎干细胞系,靶向大约70%的蛋白编码基因组(将近1.7万个基因)。
This cell bank- called Haplobank- contains over 100,000 mutated,conditional mouse embryonic stem cell lines, targeting about 70% of the protein-coding genome.为了测试这一称作为scM&T-seq的方法,该研究小组利用了处于在不同基因表达状态之间不断切换的一个时期的小鼠胚胎干细胞(ESCs)。
To test the method(called scM&T-seq), the group used mouse embryonic stem cells(ESCs) at a stage when they switch continuously between different gene-expression states.RasMAPK信号转导促进Trophectoderm从胚胎干细胞和小鼠胚胎的形成。
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.过去的研究表明人类可以使用小鼠的胚胎干细胞,造出卵子的前体--卵母细胞。
Previous studies haveshown that human beings can use mouse embryonic stem cells to produce oocytes, the precursor of eggs.在这项新的研究中,这些研究人员研究了来自小鼠的胚胎干细胞。
In the new study, the researchers studied embryonic stem cells from mice.作者分析了用m6A标记哪些RNA,以及在小鼠和人类胚胎干细胞中沿着RNA的m6A修饰的位置。
The authors analyzed which RNAs were tagged with m6A andthe location of the m6A modifications along RNAs in mouse and human embryonic stem cells.O'Donnell的研究似乎是一项2005年的研究,其中胎儿小鼠注射了人类胚胎干细胞。
It seems the research O'Donnell wasreferring to was a 2005 study in which fetal mice were injected with human embryonic stem cells.来自小鼠的胚胎干细胞通常取自早期胚胎,称为囊胚(参见InstantExpert干细胞)。
Embryonic stem cells from mice are usually taken from very early stage embryos, called blastocysts(see Instant Expert: Stem Cells)..SOX2通过调节小鼠胚胎干细胞中OCT3/4的表达来控制多能性。
Pluripotency governed by Sox-2 via regulation of Oct3/4 expression in mouse embryonic stem cells.接下来,研究人员使用了小鼠胚胎干细胞,细胞内含有鼠源DUX4基因(简称DUX)。
Next, they looked at mouse embryonic stem cells, which contain the mouse version of the DUX4 gene(called simply DUX).作为一个试点项目,Niakan计划先敲除OCT4,该基因在人类和小鼠的胚胎干细胞中均能开启。
As a pilot project, Niakan plans to knock out OCT4,a gene that is turned on in embryonic stem cells in both humans and mice.