Examples of using Genetic polymorphism in English and their translations into Romanian
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CYP 2D6 is subject to genetic polymorphism.
The genetic polymorphism in aspect of heterosis at Cucumis sativus I.
This enzyme exhibits genetic polymorphism.
Pîntea, 2008- Genetic polymorphisms in cattle improvement in Moldavia.
Both UGT1A9 andUGT2B4 are subject to genetic polymorphism.
Identification of genetic polymorphism using SSR markers;
Immune responses to the vaccine have not been studied in the context of genetic polymorphism.
Patients with genetic polymorphisms affecting CYP3A4 and CYP3A5.
The expression of CYP3A and CYP3A4 may vary by as much as 40 fold due to genetic polymorphism.
The genetic polymorphism in aspect of heterosis at Cucumis sativus I.
The clinico-paraclinical status and genetic polymorphism of chronic pancreatitis.
The genetic polymorphism relieved by means of SSR markers is extremely low, especially for the S.
Dinarica show an extremely reduced genetic polymorphism and for M. jankae is missing.
CYP2D6 genetic polymorphism has minimal impact on the mean plasma exposure to mirabegron(see section 5.2).
Dose adjustment is not considered necessary in subjects with reduced UGT1A1 activity due to genetic polymorphism.
Animal cytogenetic;- Genetic polymorphism of biochemical genetic systems;
CYP testing is necessary to adjust the dose of medication or to avoid the antipsychotics metabolized by the respective CYP,at which we find genetic polymorphisms.
Confounding factors and genetic polymorphism in the evaluation of individual steroid profiling.
A study in CYP2D6 poor metabolisers showed no evidence of a clinically significant effect of CYP2D6 genetic polymorphism on systemic exposure to umeclidinium bromide.
Analyzing effects of genetic polymorphisms on drug pharmacokinetics and efficacy in mouse models and in humans.
Around 10% of patients are at higher risk of haematological complications(cytopoenia, or a decrease in white blood cells, red blood cells or platelets)due to a possible genetic defect(partial thiopurine methyltransferase- TPMT- deficiency also known as genetic polymorphism).
UGT1A1 activity is reduced in individuals with genetic polymorphisms that lead to reduced enzyme activity such as the UGT1A1*28 polymorphism. .
Genetic polymorphisms with clinical significance at the level of P450 cytochrome enzymes that are responsible for the metabolism of most antidepressants and antipsychotic medication are at the level of CYP2D6, CYP3A4, CYP2C19, CYP1A2.
Cytochrome P450 2C9 activity is reduced in individuals with genetic polymorphisms that lead to reduced enzyme activity, such as those homozygous for the CYP2C9*3 polymorphism. .
In healthy subjects who are genotypically poor metabolisers of CYP2D6 substrates(used as a surrogate for CYP2D6 inhibition), mean Cmax and AUCinf of a single 160 mg dose of a mirabegron IR formulation were 14% and 19% higher than in extensive metabolisers,indicating that CYP2D6 genetic polymorphism has minimal impact on the mean plasma exposure to mirabegron.
Literature has shown that the genetic polymorphisms only account for a small amount of variability in concentrations of fentanyl with transdermal administration.
Theoretical value: the originality of the research consists in highlighting the clinical and evolutional peculiarities, endoscopic and morphological features of GERD depending on the degree of damage to the esophageal mucosa and the level of nitric oxide, andthe study devoted to genetic polymorphism of NOS genes and its role in the installation and development of the disease.
Published literature indicates potential for increased fentanyl exposure in patients with genetic polymorphisms affecting CYP3A4 and CYP3A5, with a small variability in concentrations with transdermal administration; therefore, IONSYS should be used with caution in these patients(see section 5.2).
The determination of quantitative and qualitative peculiarities of total andfractionated proteins allowed to put in evidence the genetic polymorphism at homo- and heterozigote sunflower's genotypes and to obtain new arguments and proofs in support of existent hypotheses and theories of heterosis, especially dominant and codominant inheritance of protein and DNA molecular components.