Sta znaci na Engleskom KLINIČKI ZNAČAJAN - prevod na Енглеском

• clinically relevant
• clinically significant
• clinically meaningful
• of clinical relevance

Примери коришћења Klinički značajan на Хрватском и њихови преводи на Енглески

Klinički značajan odgovora.
Major Clinical Responsea.

Niti jedan od tih nalaza nije klinički značajan.
Neither of these findings is of clinical relevance.

Hrana nema klinički značajan učinak na farmakokinetiku eliglustata.
Food does not have a clinically relevant effect on eliglustat pharmacokinetics.

Smatra se da taj porast nije klinički značajan.
This increase is considered unlikely to be of clinical relevance.

Hrana nema klinički značajan učinak na izloženost dimetilfumaratu.
Food does not have a clinically significant effect on exposure of dimethyl fumarate.

Malo je vjerojatno da je taj porast klinički značajan.
This increase is considered unlikely to be of clinical relevance.

In vivo nije zabilježen klinički značajan učinak na CYP3A4 vidjeti dio 4.5.
No clinically relevant effect on CYP3A4 was observed in vivo see section 4.5.

Ako klinički značajan odgovor nije postignut nakon 12 tjedana liječenja, učestalost primjene doze se može povećati na 420 mg jedanput svaka 2 tjedna.
After 12 weeks of treatment, dose frequency can be up-titrated to 420 mg once every 2 weeks if a clinically meaningful response is not achieved.

Godina, upućuje na to da dob nema klinički značajan učinak na izloženost irinotekanu i SN-38.
Years suggests that age had no clinically meaningful effect on the exposure to irinotecan and SN-38.

Ispitivanje QTc intervala na zdravim dobrovoljcima koji su primali 150 mg eltrombopaga dnevno nisu pokazala klinički značajan učinak na repolarizaciju srca.
A QTc study in healthy volunteers dosed 150 mg eltrombopag per day did not show a clinically significant effect on cardiac repolarisation.

Simeprevir nije klinički značajan inhibitor enzimske aktivnosti katepsina A.
Simeprevir is not a clinically relevant inhibitor of cathepsin A enzyme activity.

Stoga se ne očekuje da će blago ili umjereno oštećenje bubrega imati klinički značajan učinak na izloženost bedakilinu.
It is therefore not expected that mild or moderate renal impairment will have a clinically relevant effect on the exposure to bedaquiline.

Nije opažen klinički značajan učinak hrane na bioraspoloživost nomegestrolacetata.
No clinically relevant effect of food was observed on the bioavailability of nomegestrol acetate.

Na osnovi farmakokinetičkih analiza populacije, spol, dob i rasa nemaju klinički značajan učinak na farmakokinetiku idarucizumaba.
Based on population pharmacokinetic analyses, sex, age, and race do not have a clinically meaningful effect on the pharmacokinetics of idarucizumab.

Nije uočen klinički značajan učinak dabrafeniba ili njegovih metabolita na QTc interval.
No clinically relevant effect of dabrafenib or its metabolites on the QTc interval was observed.

Prema analizi podataka populacijske farmakokinetike faze I i II, dob nije imala klinički značajan utjecaj na farmakokinetiku sitagliptina.
Age did not have a clinically meaningful impact on the pharmacokinetics of sitagliptin based on a population pharmacokinetic analysis of Phase I and.

Fidaksomicin nema klinički značajan učinak na izloženost rosuvastatinu, supstratu za prijenosnike OATP2B1 i BCRP.
Fidaxomicin does not have a clinically significant effect on the exposure of rosuvastatin, a substrate for the transporters OATP2B1 and BCRP.

Ne očekuje se da će ovaj učinak lijeka koji povećava želučani pH biti klinički značajan u dnevnoj primjenu tableta ulipristalacetata.
This effect of medicinal products that increase gastric pH is not expected to be of clinical relevance for daily administration of ulipristal acetate tablets.

Rapiscan može uzrokovati klinički značajan porast krvnog tlaka, što kod nekih bolesnika može dovesti do hipertenzivne krize vidjeti dio 4.8.
Rapiscan may cause clinically significant increases in blood pressure, which in some patients can lead to hypertensive crisis see section 4.8.

Dob(65-81 godina starosti), spol, rasa(bijela, crna i Azijati) i tjelesna težina nisu imali nikakav klinički značajan učinak na farmakokinetiku alogliptina.
Age(65-81 years old), gender, race(white, black and Asian) and body weight did not have any clinically relevant effect on the pharmacokinetics of alogliptin.

Vortioksetin nije pokazao nikakav klinički značajan učinak na parametre EKG-a, uključujući QT, QTc, PR i QRS intervale u bolesnika s MDD.
Vortioxetine has not shown any clinically significant effect on ECG parameters, including the QT, QTc, PR and QRS intervals, in patients with MDD.

Populacijska farmakokinetička analiza rilpivirina u bolesnika zaraženih HIV-om pokazala je da rasa nema klinički značajan utjecaj na izloženost rilpivirinu.
Population pharmacokinetic analysis of rilpivirine in HIV infected patients indicated that race had no clinically relevant effect on the exposure to rilpivirine.

U uvjetima kliničke primjene, fidaksomicin nema klinički značajan učinak na izloženost rosuvastatinu, supstratu za OATP2B1 i BCRP vidjeti dio 4.5.
Under conditions of clinical use, fidaxomicin has no clinically relevant effect on the exposure of rosuvastatin, a substrate for OATP2B1 and BCRP see section 4.5.

Budući da je sistemska izloženost takrolimusu iz masti niska, smatra se da visoka stopa vezanja takrolimusa za proteine plazme(> 98,8%) nije klinički značajan.
As systemic exposure is low with tacrolimus ointment, the high binding of tacrolimus(> 98.8%) to plasma proteins is considered not to be clinically relevant.

S obzirom na analizu populacijske farmakokinetike, ne postoji klinički značajan utjecaj dobi, spola, rase ili etničke pripadnosti na farmakokinetiku lesinurada.
Based on population pharmacokinetic analysis, age, gender, race and ethnicity do not have a clinically meaningful effect on the pharmacokinetics of lesinurad.

Stoga se klinički značajan učinak na CYP450 supstrate s uskim terapijskim indeksom, kod kojih se doza individualno prilagođava(npr. varfarin), ne može isključiti.
Therefore, a clinically relevant effect on CYP450 substrates with a narrow therapeutic index, where the dose is individually adjusted(e.g. warfarin) cannot be excluded.

Na temelju in vitro podataka, ne očekuje se da lurasidon ima klinički značajan inhibicijski potencijal za transportere OATP1B1, OATP1B3, OCT2, OAT1, OAT3, MATE1, MATE2K ili BSEP.
Lurasidone is not expected to have a clinically relevant inhibitory potential on transporters OATP1B1, OATP1B3, OCT2, OAT1, OAT3, MATE1, MATE2K or BSEP based on in vitro data.

Budući da je očekivani metabolizam razgradnje hidroliza peptida, ne očekuje se da će oštećenje funkcije jetre utjecati na farmakokinetiku agalzidaze alfa na klinički značajan način.
As metabolism is expected to occur by peptide hydrolysis, impaired liver function is not expected to affect the pharmacokinetics of agalsidase alfa in a clinically significant manner.

Beta2-adrenergički agonisti mogu proizvesti klinički značajan kardiovaskularni učinak u nekih bolesnika kao što je ubrzanje pulsa, krvnog tlaka i/ili drugih simptoma.
Beta2-adrenergic agonists may produce a clinically significant cardiovascular effect in some patients as measured by increases in pulse rate, blood pressure, and/or symptoms.

Istovremena primjena 200 mg fidaksomicina dva puta dnevno i jedne doze od 10 mg rosuvastatina kod zdravih ispitanika nisu imali klinički značajan utjecaj na AUCinf rosuvastatina.
Co-administration of 200 mg fidaxomicin twice daily with a single dose of 10 mg rosuvastatin to healthy subjects did not have a clinically significant effect on the AUCinf of rosuvastatin.