Sta znaci na Engleskom SE OPSEŽNO METABOLIZIRA - prevod na Енглеском

• is extensively metabolised
• is extensively metabolized

Примери коришћења Se opsežno metabolizira на Хрватском и њихови преводи на Енглески

Avanafil se opsežno metabolizira u čovjeka.
Avanafil is extensively metabolised in humans.

Sofosbuvir je nukleotidni predlijek koji se opsežno metabolizira.
Sofosbuvir is a nucleotide prodrug that is extensively metabolised.

Gefitinib se opsežno metabolizira u ljudi.
Gefitinib is extensively metabolised in humans.

Amoksicilin je djelomično uništen u tijelu, a klavulanska kiselina se opsežno metabolizira.
Amoxicillin is partially destroyed in the body, and clavulanic acid is extensively metabolized.

Ivakaftor se opsežno metabolizira u ljudi.
Ivacaftor is extensively metabolised in humans.

Sirolimus se opsežno metabolizira O-demetilacijom i/ili hidroksilacijom.
Sirolimus is extensively metabolised by O-demethylation and/or hydroxylation.

Glavni sastojak u plazmi je nepromijenjeni riluzol, koji se opsežno metabolizira pomoću citokroma P450 i kasnijom glukuronidacijom.
Unchanged riluzole is the main component in plasma and is extensively metabolised by cytochrome P450 and subsequent glucuronidation.

Tolvaptan se opsežno metabolizira u jetri i to gotovo isključivo putem CYP3A.
Tolvaptan is extensively metabolised in the liver almost exclusively by CYP3A.

Tolvaptan se opsežno metabolizira u jetri.
Tolvaptan is extensively metabolised by the liver.

Silodozin se opsežno metabolizira, uglavnom putem CYP3A4, alkoholne dehidrogenaze i UGT2B7.
Silodosin is metabolised extensively, mainly via CYP3A4, alcohol dehydrogenase and UGT2B7.

Biotransformacija: duloksetin se opsežno metabolizira, a metaboliti se izlučuju prvenstveno u mokraći.
Biotransformation: Duloxetine is extensively metabolised and the metabolites are excreted principally in urine.

Sofosbuvir se opsežno metabolizira u jetri pri čemu nastaje farmakološki djelatan nukleozidni analog trifosfat GS-461203.
Sofosbuvir is extensively metabolised in the liver to form the pharmacologically active nucleoside analog triphosphate GS-461203.

Imepitoin se opsežno metabolizira prije eliminacije.
Imepitoin is extensively metabolised prior to elimination.

Vortioksetin se opsežno metabolizira u jetri primarno oksidacijom kataliziranom s CYP2D6 i u manjem opsegu s CYP3A4/5 i CYP2C9 vidjeti dio 5.2.
Vortioxetine is extensively metabolised in the liver, primarily through oxidation catalysed by CYP2D6 and to a minor extent CYP3A4/5 and CYP2C9 see section 5.2.

Indoksakarb se opsežno metabolizira u jetri u razne metabolite.
The absorbed indoxacarb is extensively metabolised by the liver to a variety of metabolites.

Aripiprazol se opsežno metabolizira u jetri, prvenstveno putem tri biotransformacijska puta: dehidrogenacije, hidroksilacije i N-dealkilacije.
Aripiprazole is extensively metabolised by the liver primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and N-dealkylation.

Takrolimus se opsežno metabolizira u jetri, primarno putem citokroma P450-3A4.
Tacrolimus is widely metabolised in the liver, primarily by the cytochrome P450-3A4.

Telaprevir se opsežno metabolizira u jetri putem hidrolize, oksidacije i redukcije.
Telaprevir is extensively metabolised in the liver, involving hydrolysis, oxidation, and reduction.

Eliglustat se opsežno metabolizira uz visoki klirens, uglavnom putem CYP2D6 i u manjoj mjeri CYP3A4.
Eliglustat is extensively metabolized with high clearance, mainly by CYP2D6 and to a lesser extent CYP3A4.

Roflumilast se opsežno metabolizira reakcijama faze I(preko citokroma P450) i reakcijama faze II konjugacijom.
Roflumilast is extensively metabolised via Phase I(cytochrome P450) and Phase II(conjugation) reactions.

Sofosbuvir se opsežno metabolizira u jetri i nastaje farmakološki aktivan nukleozidni analog trifosfat GS-461203.
Sofosbuvir is extensively metabolised in the liver to form the pharmacologically active nucleoside analog triphosphate GS-461203.

Pomalidomid se opsežno metabolizira prije izlučivanja, a nastali metaboliti eliminiraju se prvenstveno mokraćom.
Pomalidomide is extensively metabolised prior to excretion, with the resulting metabolites eliminated primarily in the urine.

Duloksetin se opsežno metabolizira oksidacijskim enzimima(CYP1A2 i polimorfnim CYP2D6) nakon čega se konjugira.
Duloxetine is extensively metabolised by oxidative enzymes(CYP1A2 and the polymorphic CYP2D6), followed by conjugation.

Silodozin se opsežno metabolizira glukuronidacijom(UGT2B7), alkoholnom i aldehidnom dehidrogenazom i oksidativnim metaboličkim putevima, uglavnom putem CYP3A4.
Silodosin undergoes extensive metabolism through glucuronidation(UGT2B7), alcohol and aldehyde dehydrogenase and oxidative pathways, mainly CYP3A4.

Nakon toga, amfenak se opsežno metabolizira u polarnije metabolite s hidroksilacijom aromatskog prstena, što dovodi do tvorbe konjugata glukuronida.
Subsequently, amfenac undergoes extensive metabolism to more polar metabolites involving hydroxylation of the aromatic ring leading to glucuronide conjugate formation.

Brimonidin se opsežno metabolizira jetrenom aldehid oksidazom, a glavni su mu metaboliti2- oksobrimonidin, 3-oksobrimonidin i 2, 3-dioksobrimonidin.
Brimonidine is extensively metabolized by hepatic aldehyde oxidase with formation of 2-oxobrimonidine, 3- oxobrimonidine and 2,3-dioxobrimonidine being the major metabolites.

Biotransformacija Febuksostat se opsežno metabolizira konjugacijom putem sustava enzima uridin difosfat glukuronoziltransferaze(UDPGT) i oksidacijom putem sustava citokroma P450(CYP).
Febuxostat is extensively metabolized by conjugation via uridine diphosphate glucuronosyltransferase(UDPGT) enzyme system and oxidation via the cytochrome P450(CYP) system.

Takrolimus se opsežno metabolizira u jetri pa, iako su koncentracije u krvi nakon topikalne terapije niske, mast je potrebno primjenjivati s oprezom u bolesnika sa zatajenjem jetre vidjeti dio 5.2.
Tacrolimus is extensively metabolised in the liver and although blood concentrations are low following topical therapy, the ointment should be used with caution in patients with hepatic failure see section 5.2.

Apremilast se opsežno metabolizira putevima sa i bez posredovanja enzima CYP, uključujući oksidaciju, hidrolizu i konjugaciju, što upućuje na to da nije vjerojatno da će inhibicija jednog puta klirensa prouzročiti izrazitu interakciju lijekova.
Apremilast is extensively metabolised by both CYP and non-CYP mediated pathways including oxidation, hydrolysis, and conjugation, suggesting inhibition of a single clearance pathway is not likely to cause a marked drug-drug interaction.

Budući da se krizotinib opsežno metabolizira u jetri, oštećenje funkcije jetre vjerojatno će povećati koncentracije krizotiniba u plazmi.
As crizotinib is extensively metabolized in the liver, hepatic impairment is likely to increase plasma crizotinib concentrations.