When sufficient numbers of MACs insert into target cell membranes the openings they create(MAC pores) mediate rapid osmotic lysis of the target cells..
Our experiments uncovered a signaling mechanism that modifies the sensitivity of target cells to SHH and consequently changes the shape of the SHH dose-response curve.
Alternatively, the obtained NK cells can be incubated with the therapeutic antibody and target cells,and the ability of one or more compounds to enhance target cell depletion can be assessed.
A cleavable linking group is one which is sufficiently stable outside the cell,but which upon entry into a target cell is cleaved to release the two parts the linker is holding together.
Unlike macrophage cells, they do not engulf and ingest target cells, but attach to them and inject chemicals that erode the membranes of the target cells until they burst.
The minimum cis-acting LTRs are sufficient for replication and packaging of a vector,which is then used to integrate the expression construct into the target cell to provide long term expression.
All the targets are used at 5000 cells per well in microtitration plate and the Effector on target ratiois indicated in the figures(usually 4 effectors per target cells).
For example, in addition to Drosophila cells and T2 cells, other cells may be used to present antigens such as CHO cells, baculovirus-infected insect cells, bacteria, yeast,vaccinia-infected target cells.
More particularly, the treatment of the disease requires the depletion of the targeted cells, preferably the diseased cells such as virally-infected cells, tumor cells or other pathogenic cells..
We will explore that the molecular mechanisms underlying recognition of NK cells andT cells against target cells in viral immunity, tumor immunity and autoimmunity.
Oligonucleotides are associated, with high instability, low bioavailability, and poor cellular uptake,making their delivery to targeted cells/tissues in the body a significant challenge.
We propose that the sensitivity of target cells to Hedgehog morphogens, and the consequent effects on gene expression and differentiation outcomes, can be controlled by signals from G protein- coupled receptors that converge on Gαs and PKA.
For example,direct cycles are initiated when HGH binds its receptors onto a target cell. The indirect HGH cycle is defined as a process when HGH is released in surges or pulses that take place during the early stages of sleep.
English
中文
عربى
Български
বাংলা
Český
Dansk
Deutsch
Ελληνικά
Español
Suomi
Français
עִברִית
हिंदी
Hrvatski
Magyar
Bahasa indonesia
Italiano
Қазақ
한국어
മലയാളം
मराठी
Bahasa malay
Nederlands
Norsk
Polski
Português
Română
Русский
Slovenský
Slovenski
Српски
Svenska
தமிழ்
తెలుగు
ไทย
Tagalog
Turkce
Українська
اردو
Tiếng việt