The A2A antagonist displayed positive effects in particular on spatial memory.
Several Nav1.7 antagonists are being explored as analgesics.CNQX(FG9065)是高效的AMPA/kainate受体拮抗剂.
CNQX(FG9065) is a potent AMPA/kainate receptor antagonist.Acenocoumarol是一种抗凝血剂,功能如同一个VitaminK拮抗剂。
Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist.Phenindione是一种抗凝血剂,作为VitaminK拮抗剂。
Phenindione is an anticoagulant which functions as a Vitamin K antagonist.Combinations with other parts of speech
米非司酮(RU486)是一种受体拮抗剂和糖皮质激素,如,可能的原因改变ACTH水平。
Mifepristone(RU486) is a glucocorticoid receptor antagonist and, as such, likely causes changes to ACTH levels.因此,这些拮抗剂构成宝贵套化学工具审问下游Hh信号机制,制订了针对Hh通路有关癌症的化疗。
These antagonists therefore constitute a valuable set of chemical tools for interrogating downstream Hh signaling mechanisms and for developing chemotherapies against Hh pathway-related cancers.Valsarta(CGP-48933)是用于治疗高血压和心力衰竭的血管紧张素II受体拮抗剂。
Valsartan(CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.Birinapant是一类名为IAP拮抗剂的药物的一部分,这种药物已经被用于研究抗癌活性。
Birinapant is part of a class of drugs called IAP antagonists, which are already being studied for anticancer activity.Wnt拮抗剂Frzb-1和新月本地规管基底膜解散发展中国家主要的嘴里。
The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth.Ambrisentan是一种选择性的ETA型受体(ETAR)拮抗剂。
Ambrisentan is a selective ET type A receptor(ETAR) antagonist.最后,我们使用TLR9拮抗剂阻断野生型NOD小鼠中的TLR9信号传导,以验证TLR9在β细胞发育和功能中的作用。
Finally, we used TLR9 antagonists to block TLR9 signalling in wild-type NOD mice to verify the role of TLR9 in beta cell development and function.AZD1979是一个Melanin-concentratinghormonereceptor1(MCHr1)拮抗剂,其IC50值约为12nM。
AZD1979 is a Melanin-concentrating hormone receptor 1(MCHr1) antagonist with an IC50 of~12 nM.拮抗剂可能不是那么敌意--他们可能的盟友是谁后同样的目标但谁不同意英雄的战术。
Antagonists may not be quites o hostile- they may be Allies who are after the same goal but who disagree with the hero's tactics.这样,X射线分析使团队能够看到CB2的结构以及它如何与阻断分子或拮抗剂连接。
That way, the X-ray analysis allowed the team to see both the structure of CB2 andhow it connects to the blocking molecule, or antagonist.Iadonato博士说,“α9/α10nAChR拮抗剂已经在几个临床前动物模型中表现出镇痛特性。
Iadonato says the α9/α10 nAChR antagonists have“demonstrated analgesic properties in several pre-clinical animal models.SB-568849是一种黑色素浓缩激素受体1(MCHR1)拮抗剂,pKi值为7.7。
SB-568849 is a melanin-concentrating hormone receptor 1(MCH R1) antagonist with a pKi of 7.7.这真的显示了我们转化这些发现的能力,并且建议Msi拮抗剂可以用于靶向化疗耐药性的新策略。
This really highlights our ability to translate these findings andsuggests that Msi antagonists could be a new strategy for targeting resistance to chemotherapy.”.CP316311是一种有效的,选择性的CRF1receptor拮抗剂,IC50值为6.8nM。
CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.H4Rantagonist1是一种有效的高选择性组胺H4受体(H4R)拮抗剂,IC50为27nM。
H4R antagonist 1 is a potent and highly selective histamine H4 receptor(H4R) antagonist with an IC50 of 27 nM.NESS-0327是一种用于科学研究的药物,它作为大麻素受体CB1的一种极有效的选择性拮抗剂。
NESS-0327 is a drug used in scientific research which acts as an extremely potent andselective antagonist of the cannabinoid receptor CB1.LosartanCarboxylicAcid(E-3174)是Losartan的活性羧酸代谢产物,是血管紧张素Ⅱ受体1型(AT1)拮抗剂。
Losartan Carboxylic Acid(E-3174), an active carboxylic acid metabolite of Losartan,is an angiotensin II receptor type 1(AT1) antagonist.YM158freebase是一种有效的选择性LTD4和TXA2受体拮抗剂,pA2值分别为8.87和8.81。
YM158 free base is a potent and selective LTD4 andTXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively.Zibotentan(ZD4054)是一种特异性的Endothelin(ET)A拮抗剂,IC50为21nM,对ETB没有抑制活性。
Zibotentan(ZD4054) is a specific Endothelin(ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB.Guggulsterone,一种法尼醇X受体(FXR)拮抗剂,可降低CDCA诱导的FXR活化,Z-和E-Guggulsterone的IC50分别为17和15μM。
Guggulsterone, a farnesoid X receptor(FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.最近的研究表明,CB2拮抗剂可以改善肾纤维化,也可以延缓肿瘤的进展,表明其作为治疗纤维疾病和癌症的化合物的潜力。
Recent studies indicate that CB2 antagonists can ameliorate renal fibrosis and also delay tumor progression, indicating their potential for treating fibrotic conditions and cancer.A-740003是一种有效的,选择性的,竞争性的P2X7receptor拮抗剂,抑制大鼠和人的P2X7受体,IC50值分别为18和40nM。
A-740003 is a potent, selective and competitive P2X7 receptor antagonist with IC50 values are 18 and 40 nM for rat and human P2X7 receptors, respectively.仅有一项53名婴儿参与的评价预防上消化道出血的试验,结果显示H2受体拮抗剂组与未接受治疗组的婴儿死亡率无差异;.
A single trial with 53 infants assessing prevention of upper gastrointestinal bleeding reported no difference inmortality in infants assigned H2 receptor antagonist versus no treatment;Zibotentan(ZD4054)是一种特异性的Endothelin(ET)A拮抗剂,IC50为21nM,对ETB没有抑制活性。
Description: Zibotentan(also known as ZD4054) is a specific Endothelin(ET)A antagonist with IC50 of 21 nM, it exhibits no activity at ETB.然后的基督徒,阿比西尼亚的国王,一个名为“拮抗剂”敌基督的排序的帮助下,将游行反对Caaba麦加。
Then the Christians, aided by the King of Abyssinia,a sort of Antichrist named"The Antagonist", will march against the Caaba in Mecca.