It's scientifically known as Gc protein-derived macrophage activating factor.研究小组发现缺乏PPAR-的巨噬细胞不能将谷氨酸胺作为能量来源,因此更容易受到炎症刺激。
The team found that macrophages lacking PPAR gamma are unable to use glutamine as an energy source and therefore are more susceptible to inflammatory stimulation.检查的乳腺癌患者中有75%表现出与增加的巨噬细胞浸润和肿瘤进展相关的IGF受体的激活。
Of breast cancer patients examined showedactivation of IGF receptors which correlates with increased macrophage infiltration and tumour progression.感染分枝杆菌的人类巨噬细胞也使用铜来攻击细菌,但它们以不太复杂的方式进行。
Human macrophages infected with Mycobacteria also use copper to attack the bacteria, but they do so in a less sophisticated way.现在,我们将使用来自C57黑鼠的巨噬细胞,这些小鼠对寄生虫具有抗性。
Now, we're going to use macrophages from C57 black mice, which are resistant to the parasite.Combinations with other parts of speech
他们会更容易起兵反对的巨噬细胞和少量的军队onkokletok,而不是抗肿瘤的舰队战斗。
They will be easier to raise an army to fight against the macrophage and small in size onkokletok army, not against an armada of tumor.在整个免疫治疗机制的巨噬细胞是非常重要的,”Leftin博士指出。
Macrophages are really critical in the whole immune therapy mechanism,” Dr. Leftin points out.他们确定了三个表达CD73的巨噬细胞簇,尽管进行了派姆单抗治疗仍然存在。
They identified three CD73-expressing macrophage clusters that persisted despite pembrolizumab treatment.Sharma及其同事指出,表达CD73的巨噬细胞的流行可能导致缺乏杀死肿瘤的T细胞反应和不良的临床结果。
Sharma and colleagues note the prevalence of CD73-expressing macrophages likely contributed to lack of tumor-killing T cell responses and poor clinical outcome.由于HIV感染而激活的组织巨噬细胞可以开启或促成疾病过程,例如心血管疾病和神经疾病,”麦格拉思说。
Tissue macrophages, activated due to HIV infection, can turn on or contribute to disease processes, such as cardiovascular disease and neurological disease,” said McGrath.将来,细菌可能能够揭示肿瘤的位置并且还能够检测到增加的巨噬细胞活性。
In future, bacteria may be able to reveal the location of a tumor andalso detect increased macrophage activity.通常,血液中循环的巨噬细胞迁移到感染部位,一旦病毒侵入,就可以与之抗争。
Usually, macrophages circulating in the bloodstream migrate to an infection site to fight a virus once it has invaded.作为对照实验,研究人员使用含有无效iSNAPS的巨噬细胞,其仅具有感应但没有激活能力。
As a control experiment, the researchers used macrophages containing disabled iSNAPS, which have sensing capability but no activating capability.这些发现进一步提供证据表明携带活跃的HIV的巨噬细胞可能将HIV运送到大脑中,从而导致感染者存在认知问题。
These findings add to growing evidence that macrophages harboring active HIV may transport HIV to the brain, leading to cognitive problems in infected people.此外,研究人员鉴定出来源骨髓的巨噬细胞是导致胰岛素抵抗的Gal3的来源。
Furthermore, investigators identified bone marrow-derived macrophages as the source of Gal3 that leads to insulin resistance.在这些患者的肺部,医生发现大量的免疫细胞含有大量的油性液滴,称为富含脂质的巨噬细胞。
Within the lungs of these patients, doctors found large immune cells containing numerous oily droplets,called lipid-laden macrophages.Sieweke研究小组已证实,在实验室培养物中培育的巨噬细胞没有丧失它们的特性。
Sieweke's teams have already shown that macrophages grown in laboratory cultures do not lose their properties.这些巨噬细胞含有高水平的表面酶,称为CD73,这些独特的巨噬细胞通常与胶质母细胞瘤有关。
These macrophages contain high levels of surface enzyme called CD73 and these unique macrophages are commonly seen associated with glioblastomas.此外,我们还表示,即使是ART,生产性感染的巨噬细胞仍然可以持续存在;
In addition, we show that productively infected macrophages can persist despite ART;几年前,他的研究小组已发现在脂肪组织中发现的巨噬细胞吸收并“消化”大量脂质。
Several years ago, his research team found that the macrophages found in fat take up and‘digest' large amounts of lipid.Dixit实验室发现了一种新型的巨噬细胞,它存在于腹部脂肪的神经中。
The Dixit lab discovered a new type of macrophage that resides on the nerves in belly fat.进一步研究发现,肿瘤部位的巨噬细胞可以通过一种名为SIGLEC-10的受体感知CD24信号。
In further studies, the scientists showed that the macrophage cells that infiltrate the tumor can sense the CD24 signal through a receptor called SIGLEC-10.它们招募的细胞之一就是另一类被称作M2的巨噬细胞,它们降低炎症和促进组织修复。
One of the cells they recruit is a second kind of macrophage, dubbed M2, that decreases inflammation and encourages tissue repair.下一步就是鉴定出组织再生所必需的巨噬细胞激活的组分。
The next step is to identify the components of macrophage activation that are necessary for regeneration.它还对库普弗细胞的功能产生不利影响,库普弗细胞是专门的巨噬细胞,有助于防止细菌进入胆道系统。
It also adversely affects the function of Kupffer cells,which are specialized macrophage cells that assist in preventing bacteria from entering the biliary system.这项新的研究表明,许多生长缓慢的NF1胶质瘤含有很少的巨噬细胞,并产生一种叫做新抗原的蛋白质,可以引发免疫系统攻击。
The new studyrevealed that many slow-growing NF1 gliomas contain few macrophages and produce proteins, called neoantigens, that can trigger an immune system attack.Gc-MAF(Gc蛋白衍生的巨噬细胞激活因子)天然存在于我们的体内,并通过激活它们来指导巨噬细胞破坏癌细胞和外来侵略者.
GcMAF(Gc Protein derived Macrophage Activating Factor) occurs naturally in our bodies and instructs macrophages to destroy cancerous cells and foreign invaders by activating them.随着个体年龄的增长,这种原始的巨噬细胞供应被来自骨髓和血液的较少再生和更具炎症的巨噬细胞所取代。
As individuals age, this original macrophage supply is replaced by less regenerative and more inflammatory macrophages coming from bone marrow and blood.有两大类与肿瘤相关的巨噬细胞或TAM:M1和M2。
There are two broad categories of tumor-associated macrophages, or TAMs: M1 and M2.