The researchers say finding these structural variants is important for several reasons.
They found nearly 69,000 structural variants.
They found nearly 69,000 differences, known as structural variants.该图显示了大约20,000个结构变异,由于长期流行的基因组测序方法的技术限制,其中很少有人注意到。
The map reveals about 20,000 structural variations, few of which have ever been noted due to technological limitations in a long-popular method of genome sequencing.研究人员观察到,一些结构变异似乎会影响DNA非编码序列中的调控基因“开关”。
What the researchers observed is that some structural variants appear to affect regulatory gene“switches” in noncoding sequences of DNA.Combinations with other parts of speech
截至2006年,高分辨率CGH(HR-CGH)阵列能以200bp的分辨率准确检测结构变异(SV)。
As of 2006, even high-resolution CGH(HR-CGH)arrays are accurate to detect structural variations(SV) at resolution of 200 bp.总的来说,结构变异与DNA甲基化的整体水平下降有关。
Overall, structural variation was associated with a global decrease in DNA methylation.虽然在正常肝细胞,结构变异,包括chromothripsis罕见,是肝硬化突出。
Although rare in normal hepatocytes, structural variants, including chromothripsis, were prominent in cirrhosis.Mo17和其他玉米基因组之间广泛的种内基因顺序和基因结构变异.
Extensive intraspecific gene order and gene structural variations between Mo17 and other maize genomes.
Structural variation appears to be quite common, affecting around 12 per cent of the genome.研究人员观察到,一些结构变异似乎会影响DNA非编码序列中的调控基因“开关”。
What the researchers were able to observe is that some structural variants appear to affect regulatory gene"switches" in noncoding sequences of DNA.使用他们的新方法,研究人员能够找到30多种癌细胞的结构变异。
This new method has enabled the researchers to find structural variations for over 30 types of cancer cells.结构变异:影响DNA块的变化,从而可以改变整个染色体的结构。
Structural variation: changes affecting chunks of DNA which can consequently alter the structure of the entire chromosome.科学家团队也能够使用相同的方法开始了解为什么某些类型的结构变异可能导致癌症。
Scientists are also able to use themethod to study why certain classes of structural variants may contribute to cancers.这表明,随着基因组学进入临床,儿科患者的诊断检测必须包括拷贝数变化和结构变异,”Zhang说。
This shows that as genomics moves into the clinic, diagnostic testing for pediatricpatients must include copy-number changes and structural variations,” Zhang said.这种分析识别出人类和特定猿谱系特异性的基因组结构变异。
This analysis recognized genomic structural variation specific to humans and particular ape lineages.这组科学家还使用了同样的方法来开始学习为什么某些类型的结构变异可能会导致癌症。
The team of scientists also used the same methods tobegin to learn why certain classes of structural variants may be contributing to cancers.在BioNanoGenomics公司2017年2月商业推出Saphyr系统之前,市场上没有任何产品可以全面,兼顾成本和时间有效地检测结构变异。
Until the launch of Saphyr in February 2017,no products existed that could detect structural variation as accurately and efficiently as Saphyr.科学家团队也能够使用相同的方法开始了解为什么某些类型的结构变异可能导致癌症。
The team of scientists also used the same methods tobegin to learn why certain classes of structural variants may be contributing to cancers.这组科学家还使用了同样的方法来开始学习为什么某些类型的结构变异可能会导致癌症。
Scientists are also able to use themethod to study why certain classes of structural variants may contribute to cancers.Lee博士是研究基因组结构变异及其在疾病中的作用的专家。
Dr. Lee is an expert on structural variants in genomes and their roles in disease.这就解释了以下的事实,即在大分子中,多糖携带的生物学信息最大,因为它们具有最大的结构变异能力。
This explains the fact that, among macromolecules, polysaccharides provide the highest capacity for carrying biological information,as they have the greatest potential for structural variability.
Variation of structure:.CNV是基因组结构变异(Structuralvariation,SV)的重要组成部分。
CNV is a form of structural variation(SV) in the genome.利用他们的新方法,研究人员发现了30多种癌细胞的结构变异。
Using their new method,the researchers were able to find structural variations for over 30 types of cancer cells.使用他们的新方法,研究人员能够找到30多种癌细胞的结构变异。
Using their new method,the researchers were able to find structural variations for over 30 types of cancer cells.全基因组测序可检测单核苷酸变异、插入/缺失、拷贝数改变和大的结构变异。
Whole-genome sequencing can detect single nucleotide variants, insertions/deletions, copy number changes,and large structural variants.该研究提供了一套较为完整的基因组变异,提供了研究大型基因组结构变异的影响的可能性。
The study provides a complete set of genomic variants,providing the possibility of studying the effects of structural variation in large genomes.他们测试了这种结构的变异,最终找到一种似乎与催产素具有相似性状而没有其缺点的结构。
They tested variations of this structure, eventually finding one that appeared to have similar traits as oxytocin without its drawbacks.第二篇Nature论文中,科学家们调查了2,504个样本中的基因组结构变异。
In a companion paper in Nature,scientists examined differences in the structure of the genome in the 2,504 samples.