Notch(left) and Seananners(right) at the Machinima Realm Minecraft Interview; February 11, 2011.
然而,阻止异常Notch信号激活和与细胞命运相关的潜在有害决定的分子机制仍不清楚。
However, the molecular mechanisms that prevent abnormal Notch signaling activation and potentially harmful decisions related to cell fate remain unclear.”.
这项研究之前,有研究推测基于notch途径的细胞间可以互相牵拉,打开并且激活notch途径。
Prior to this study, studies have speculated that cells based on the Notch pathway can pull each other and activate the Notch pathway.
由于Notch信号通路广泛存在并且发生在大多数生物中,研究人员希望这些发现也可以转移到人类身上。
Since the Notch signaling pathway is widespread and occurs in most organisms, the researchers hope that the findings can also be transferred to humans.
Lim介绍,原则上科学家能设计Notch感应人造分子,包括那些研究人员利用构建器官的支架。
In principle, Lim said, scientists could engineer Notch to sense man-made molecules, including those in the scaffolds that researchers are using to build organs.
The identified signalling pathway is called Notch and is activated by interactions between so-called Notch receptors(Notch1-4) and their target molecules on neighbouring cells.
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