We find that, on average, an iPSC line manifests two copy number variants(CNVs) not apparent in the fibroblasts from which the iPSC was derived.
新的研究得出结论,在研究自然选择驱动的进化变化时,分析拷贝数变异是一个重要的工具。
The new research concludes that analyzing copy number variants is an important tool when investigating evolutionary changes driven by natural selection.
拷贝数的多潜能和细胞扩散基因在人类胚胎干细胞和魔鬼期间重新编程和文化在时间中的动态变化。
Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture.
As with most cancers, triple-negative breast cancer(TNBC)cells have abnormal amounts of chromosomes or DNA copy number aberrations(CNAs) in their genomes.
Researchers analyzed tumors for genetic mutations, gene copy number(deletions and amplifications), gene expression of messenger RNA, microRNA and protein expression, among other factors.
这表明,随着基因组学进入临床,儿科患者的诊断检测必须包括拷贝数变化和结构变异,”Zhang说。
This shows that as genomics moves into the clinic,diagnostic testing for pediatric patients must include copy-number changes and structural variations,” Zhang said.
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