Thus, c-FLIP inhibits apoptosis and dampens NF-κB downstream of CD95 but allows NF-κB activation to a level sufficient for ccRCC cell survival.
一个过程是细胞凋亡,一种基因导向的程序性细胞死亡形式,可以去除不必要的,老化的或受损的细胞。
One process is apoptosis, a form of gene-directed programmed cell death which removes unnecessary, aged, or damaged cells.
尽管科学家在过去十年中已经提出细胞凋亡并不总是最终的,但仍然存在对这些结果的普遍怀疑。
As much as scientists in the past decade have suggested that apoptosis is not always final, there is still widespread skepticism regarding these results.
这些结果突出显示辐射诱导细胞凋亡是复杂和修改由基因型、膳食补充剂和性别。
These results highlight that radiation-induced apoptosis is complex and is modified by genotype, dietary supplements and gender.
我们的最终目标就是将这些针对细胞凋亡的创新性疗法带给饱受癌症病痛的患者。
The ultimate goalis to bring these innovative therapies targeting apoptosis to patients suffering from cancer.
首先,它们能抵抗细胞凋亡(导致细胞死亡的过程)并在恶劣的肿瘤环境中存活。
First, they could resist apoptosis(processes that lead to cell death) and survive in the hostile tumor environment.
细胞可以存活数天,数月甚至数年,但是一旦细胞凋亡开始,它就不会花费任何时间来进行死亡。
Cells can live for days, months, even years,but once apoptosis starts, it takes no time at all for death to set in.
然而,细胞凋亡或坏死的诱导主要通过TNFR1实现,TNFR1也称为死亡受体。
However, induction of apoptosis or necrosis is mainly achieved through TNFR1, which is also known as a death receptor.
However, the apoptotic mechanisms decline with age,and if neither DNA repair mechanism nor apoptosis occurs, cutaneous tumorigenesis may result.
化疗药物通常被设计成通过破坏DNA来杀死恶性细胞,直到它们转变为程序性死亡模式称为细胞凋亡。
Chemotherapy drugs are often designed to kill off malignant cells by damaging their DNA until theytransition to a programmed death mode called apoptosis.
Each of the three genes(eat-2, isp-1 and clk-1) suppressed cell division,even though they did not appear to increase apoptosis.
此外CD14在调节树突细胞凋亡、预测心血管事件及评估慢性肾脏疾病预后中起着重要作用。
In addition,CD14 plays an important role in regulating dendritic cell apoptosis, predicting cardiovascular events, and assessing the prognosis of chronic kidney disease.
细胞凋亡一旦开始便无法停止,它是一个高度调控的过程。
Because apoptosis cannot stop once it begins, it is a highly regulated process.
细胞凋亡在健康和疾病的调节:Bcl-2家族蛋白的平衡。
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.
卢说,到目前为止,科学家们主要集中精力分析导致细胞凋亡的一系列事件。
To date, Lu said, scientists have largely focused theirefforts on analyzing the cascade of events that leads to apoptosis.
其生物学功能包括抗原的表达、参与免疫调节、免疫监视的逃避、逃避细胞凋亡、耐药等。
Its biological functions include antigen expression, participation in immune regulation, escape from immune surveillance,escape from apoptosis, and drug resistance.
然后激活caspase9,促进caspase3和7的下游活化,从而导致细胞凋亡。
Activation of caspase 9 then facilitates the downstream activation of caspases 3 and7 resulting in apoptosis.
他们证明20E通过GPCR引起快速的钙离子流入,促进细胞凋亡和变态。
They proved that the 20E via GPCRs causes a rapid calcium ion influx,promotes cell apoptosis and metamorphosis.
应用TUNEL法检测朱庇特的视频开始讨论如何使用这种技术来检测细胞凋亡。
JoVE's video on the TUNEL assay begins by discussing how thistechnique can be used to detect apoptotic cells.
如果ROS不断积累,一旦超过死亡阈值,则会导致细胞凋亡。
If ROS continues to accumulate and exceed the threshold of death,it will cause cell apoptosis.
该通道的过度表达和错误调节可导致细胞凋亡,导致体内多种疾病。
Over expression and misregulation of this pore could lead to apoptosis in the cell leading to a variety of diseases within the body.
一方面Trk受体具有明确的营养作用,但另一方面p75受体激活的信号通路也能导致细胞凋亡。
Whilst the Trk receptors have a clearly defined trophic role,p75 receptors activate signalling pathways which can also result in apoptosis.
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