A number of organism-specific transcriptome databases have been constructed and annotated to aid in the identification of genes that are differentially expressed in distinct cell populations.
他们应用唾液转录组数据与有患者人口统计学,症状和危险因素相关的因素一起。
They used salivary transcriptomic data along with factors related to patient demographics, symptoms and risk factors.
转录组:由一个有机体的DNA产生的全套RNA“读数”.
Transcriptome: the complete set of RNA“readings” produced from an organism's DNA.
您真的是在追踪细胞的转录组,还是仅仅在读取平均值??
Are you truly tracking your cells' transcriptomes, or are you just reading into the averages?
转录组分析显示照片的突变影响在厌氧条件下~355基因的表达。
Transcriptome analysis revealed that mutation of airR impacts the expression of∼355 genes under anaerobic conditions.
不只是对基因组,还有转录组和蛋白质组以及其他数据形式。
And it's not just genomes; it's transcriptomes and proteomes and many other data modalities.
总体而言,与NCBI预测的转录组相比,转录组多样性增加了四倍。
Overall, a four-fold increase in transcriptome diversity compared to the NCBI predicted transcriptome was achieved.
通过观察内含子,研究人员首次研究了所谓的新生转录组-新合成的基因表达。
Looking at introns enabled the researchers to examine, for the first time,so-called nascent transcriptomes- newly synthesized gene expression.
研究人员汇集了每个人转录组的信息,这是一组揭示DNA表达模式的分子的集合;.
The researchers pooled information from each person's transcriptome, a collection of molecules that reveal patterns of DNA expression;
在上一单元中,我们简要介绍了转录组数据挖掘的基本概念与非编码RNA的相关背景.
In last unit,we have made a brief introduction to the basic concepts of transcriptome data mining and the background knowledge of non-coding RNAs.
不同细胞类型的基因组可能是相同的,但是它们的表观基因组和转录组不是相同的。
The genomes of different types of cells may be identical,while their epigenomes and transcriptomes are not.
CITE-seq增加了已经建立的转录组分析方法,对产生数据的质量没有任何不利影响。
CITE-seq adds to already established methods for transcriptome analysis without any detrimental effects on the quality of the data generated.”.
但它们的转录组签名根本不匹配,这意味着它们不是我们原先认为的动物生命的核心构建块。
But their transcriptome signatures simply don't match, meaning that these aren't the core building blocks of animal life that we originally thought they were.
然后,他们对转录组数据应用了一系列计算步骤,以比较四种不同药物的效果。
Then, they applied a series of computational steps to the transcriptome data in order to compare the effects of the four different drugs.
在每个细胞中,他们获得了充分的覆盖度研究数千基因的表观遗传和转录组多样性。
For each cell,they obtained sufficient coverage to study epigenetic and transcriptome diversity of several thousand genes.
We hope that this instrumentlowers the hurdles associated with performing single-cell transcriptome profiling experiments in basic research and clinical settings,” Dr. Stephenson said.
完成本模块的课程后你将可以:掌握从转录组数据中分析非编码RNA的方法;.
Upon completion of this module, you will be able to:Analyze non-coding RNAs from transcriptome data;
在他博士期间,他开发了用于分析高通量转录组数据的计算机方法。
During his PhD he developed computational methods for the analysis of high-throughput transcriptome data.
一个方法是检查转录组(被表达的全套基因)的变化。
One method is to examine changes in the transcriptome- the entire set of genes that are expressed.
转录组可以被视为蛋白质组的前体,即由基因组表达的整组蛋白质。
The transcriptome can be seen as a subset of the proteome, that is, the entire set of proteins expressed by a genome.
转录组研究是基因功能及结构研究的基础和出发点。
The transcriptome study is the basis and starting point for the study of gene function and structure.
给予维生素C(100μM)在乳腺癌mda-mb-231细胞增加了5hmc内容,显著改变了转录组。
Treatment with vitamin C(100 μM) increased the 5hmC content in MDA-MB-231 breast cancer cells andmarkedly altered the transcriptome.
健康的大脑发育和神经功能依赖于转录组的精确时空调控,而转录组在不同大脑区域和细胞类型中有很大差异。
Healthy brain development andneurological function rely on precise spatiotemporal regulation of the transcriptome, which varies substantially by brain region and cell type.
尽管我们身体每个细胞中的基因组都基本相同,每种细胞类型的转录组却并不一样,且不断地在发生变化。
While the genome is essentially the same in every cell in our bodies, the transcriptome is different in each cell type and constantly changing.
This observation, combined with the transcriptomic data, told us that cells transition through an intermediate state before becoming 2-cell-like cells”,- said Maria Elena Torres-Padilla.
癌症转录组包括RNA为基础的改变,包括mRNA的变化。
The cancer transcriptome involves RNA-based alterations, including changes in messenger RNAs.
以外,转录组反映了在任何给定时间内活跃表达的基因。
The transcriptome reflects the genes that are being actively expressed at any given time.
以外,转录组反映了在任何给定时间内活跃表达的基因。
The transcriptome reflects the genes which are actively expressed in given moment.
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