People suffering from the disruption of the liver functioning should reduce the initial dose of Duloxetine or reduce the frequency of taking this drug.
パニック障害およびPTSD:Asentra初期投与量が25mg1日1回、朝または夕方である場合。
Panic disorder and PTSD: the initial dose is 25 mg once a day, in the morning or in the evening.
The modified-release tablet: the initial dose- 30 mg; further dose increase can not earlier than 2 Sun; The maximum daily dose- 120 mg 1 once a day during breakfast.
In patients with mild to moderate hepatic impairment, induced liver metastases, with mild renal insufficiency(Creatinine CL 51-80 mL/min)correction of the initial dose is required.
Inside, 1 once a day(morning), the initial dose- 10 mg(bad Portability can receive 5 mg); in the case of lack of effectiveness through 4 week increase the dose to 15 mg/ day.
In chronic heart failure, in postinfarctne period: initial dose is on 6,25 mg 3 times per day with a subsequent increase in(every 2-3 weeks) until maintenance dose 25 mg 2-3 times a day or to 50 mg 3 once a day in postinfarctne period.
The syndrome Zollinger- Ellison: the initial dose- 12 mg every 6 no, further adjusting the dose of; for the prevention of aspiration of gastric contents prior to general anesthesia: 20 mg per day of operation or at least 2 hours before its start.
When hypertension: the initial dose- 12,5 mg 2 once a day, the single dose increase to 50 mg 3 times a day at intervals of 2-4 weeks; maintenance dose 25 mg 2-3 times a day; The maximum daily dose- 150 mg.
If hypothyroidism is the initial dose of 25-100 μg per day, gradually increasing(on 25-50 mcg every 2-3 weeks) to support- 125-250 mcg per day, after surgery for malignant tumors of the thyroid gland is to 300 mcg per day.
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