In certain embodiments, samples may be derived from the liver(e.g.,whole liver or certain segments of liver or certain types of cells in the liver, such as, e.g., hepatocytes).
Although we may be able to target and kill visible tumor cells,a population of other types of cells in the tumor are resistant to the treatment and continue to proliferate.
And while we can sometimes introduce new DNA sequences into cells to replace the DNA sequences surrounding a cut site, that process, unfortunately,doesn't work in most types of cells, and the disrupted gene outcomes still predominate.
However, two types of cells in the olfactory epithelium(specialized tissue responsible for sense of smell), are mixed together and form a mosaic pattern despite expressing different types of cadherins.
These data demonstrate cell-cell cooperativity between different cell types in mediating chemotactic events and provide one potential explanation for the clinically observed effect of CD8+ cells on bone marrow transplantation.
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