Приклади вживання Hinokitiol Англійська мовою та їх переклад на Українською
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Products containing Hinokitiol.
Hinokitiol has been shown to restore hemoglobin production in rodents.
One of the leading brands in the sale of consumer hinokitiol products is Hinoki Clinical.
Hinokitiol is structurally related to tropolone, which lacks the isopropyl substituent.
This study was done with the zinc ionophore pyrithione,which functions very similarly to Hinokitiol.[18].
Hinokitiol is a Zinc and Iron Ionophore, additionally it is approved as a food additive.[6].
Beginning in the 2000s, researchers recognised that hinokitiol could be of value as a pharmaceutical, notably for inhibiting the bacterium Chlamydia trachomatis.
Hinokitiol was discovered in 1936 by Dr. Tetsuo Nozoe from the essential oil component of Taiwan cypress.
In a similar study on zebrafish, the molecule restored Hemoglobin production.[62]A commentary on the work of Burke et al. nicknamed hinokitiol the“Iron Man molecule”.
In cell cultures, hinokitiol inhibit human rhinovirus, coxsackievirus, and mengovirus multiplication.
Nozoe's documented work in Formosa concerned the chemical components of Taiwanhinoki, a native conifer growing in mountainous areas.[55]Nozoe determined a new compound, hinokitiol, from the components of this species and reported it for the first time in 1936 in a special issue of Bulletin of the Chemical Society of Japan.[56].
Hinokitiol interferes with the processing of viral polyproteins, thus inhibiting picornavirus replication.
Another brand, namely,'Relief Life',[36] has boasted over a million saleswith their‘Dental Series' toothpaste containing hinokitiol.[37] Other notable producers ofhinokitiol based products include Otsuka Pharmaceuticals, Kobayashi Pharmaceuticals, Taisho Pharmaceuticals, SS Pharmaceuticals.
Hinokitiol(β-thujaplicin) is a natural monoterpenoid found in the wood of trees in the family Cupressaceae.
When a symposium,"Tropolone and Allied Compounds" was organised by the Chemical Society of London in November 1950, Nozoe's work on hinokitiol was mentioned as a pioneering contribution to tropolone chemistry, thereby helping Nozoe's research gain recognition in the West.[57] Nozoe was able to publish his work on hinokitiol and its derivatives in Nature in 1951 thanks to J.W. Cook, the chairman of the symposium.
Hinokitiol acts as an iron ionophore to channel iron into cells,[20][21] increasing intracellular iron levels.
In addition to broad-spectrum antimicrobial activity, Hinokitiol also possesses anti-inflammatory and anti-tumour activities, characterised in a number of in vitro cell studies and in vivo animal studies.
Hinokitiol has a broad range of biological activities, many of which have been explored and characterised in literature.
Further work by the team established the mechanism by which hinokitiol restores or reduces cell iron.[61] They then switched their study to mammals and found that when rodents that had been engineered to lack“iron proteins” were fed hinokitiol, they regained iron uptake in the gut.
Hinokitiol was found to exert cytotoxicity on several prominent cancer cell lines by inducing autophagic processes.[16][17].
Hinokitiol inhibits key inflammatory markers and pathways, such as TNF-a and NF-kB, and its potential for treatment of chronic inflammatory or autoimmune conditions is being explored.
Hinokitiol is a documented Zinc Ionophore, however more research is required at this time to establish effective concentrations of delivery methods for Hinokitiol and Zinc.
Hinokitiol inhibits the replication of picornaviruses by impairing the viral polyprotein processing and that the antiviral activity of hinokitiol is dependent on the availability of zinc ions.[19].
In 2006, hinokitiol was categorised under the Domestic Substances List in Canada as non-persistent, non-bioaccumulative& non-toxic to aquatic organisms.[40] EWG has dedicated a page to the ingredient hinokitiol indicating that it is'low hazard' in areas such as"Allergies& Immunotoxicity","Cancer"&"Developmental& Reproductive Toxicity".
Hinokitiol enables the influx of zinc ions into cells, which inhibit the replication machinery of RNA viruses, and subsequently inhibiting the replication of the virus.[15] Some notable RNA viruses include the human influenza virus, SARS.[18] Zinc ions were able to significantly inhibit viral replication within cells, and proved that the action was dependent on zinc influx.