Примери за използване на Darunavir AUC на Английски и техните преводи на Български
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Mg once daily darunavir AUC↔ darunavir Cmin↔ darunavir Cmax↔.
Mg once daily atazanavir AUC↔ atazanavir Cmin↑ 52% atazanavir Cmax↓ 11% darunavir AUC↔.
Mg twice daily darunavir AUC↔ darunavir Cmin↔ darunavir Cmax↔.
Mg once daily efavirenz AUC↑ 21% efavirenz Cmin↑ 17% efavirenz Cmax↑ 15% darunavir AUC↓ 13% darunavir Cmin↓ 31%.
Mg once daily darunavir AUC↔ darunavir Cmin↓ 11% darunavir Cmax↔ rilpivirine AUC↑ 130% rilpivirine Cmin↑ 178% rilpivirine Cmax↑ 79%.
Mg once daily atazanavir AUC↔ atazanavir Cmin↑ 52% atazanavir Cmax↓ 11% darunavir AUC↔ darunavir Cmin↔ darunavir Cmax↔.
Rifabutin Cmax darunavir AUC↑ 53% darunavir Cmin↑ 68% darunavir Cmax↑ 39% sum of active moieties of rifabutin(parent drug+ 25-O-desacetyl metabolite).
Lopinavir/ritonavir 533/133.3 mg twice daily lopinavir AUC↑ 9% lopinavir Cmin↑ 23% lopinavir Cmax↓ 2% darunavir AUC↓ 38%‡.
Mg once daily efavirenz AUC↑ 21% efavirenz Cmin↑ 17% efavirenz Cmax↑ 15% darunavir AUC↓ 13% darunavir Cmin↓ 31% darunavir Cmax↓ 15%(↑ efavirenz from CYP3A inhibition)(↓ darunavir from CYP3A induction).
Carbamazepine 200 mg twice daily carbamazepine AUC↑ 45% carbamazepine Cmin↑ 54% carbamazepine Cmax↑ 43% darunavir AUC↔ darunavir Cmin↓ 15% darunavir Cmax↔.
Tenofovir disoproxil 245 mg once daily tenofovir AUC↑ 22% tenofovir Cmin↑ 37% tenofovir Cmax↑ 24% darunavir AUC↑ 21% darunavir Cmin↑ 24% darunavir Cmax↑ 16%(↑ tenofovir from effect on MDR-1 transport in the renal tubules).
Etravirine 100 mg twice daily etravirine AUC↓ 37% etravirine Cmin↓ 49% etravirine Cmax↓ 32% darunavir AUC↑ 15% darunavir Cmin↔ darunavir Cmax↔.
ANTIBIOTIC Clarithromycin 500 mg twice daily clarithromycin AUC↑ 57% clarithromycin Cmin↑ 174% clarithromycin Cmax↑ 26% darunavir AUC↓ 13% darunavir Cmin↑ 1% darunavir Cmax↓ 17% 14-OH-clarithromycin concentrations were not detectable when combined with PREZISTA/ritonavir.
Rilpivirine 150 mg once daily rilpivirine AUC↑ 130% rilpivirine Cmin↑ 178% rilpivirine Cmax↑ 79% darunavir AUC↔ darunavir Cmin↓ 11% darunavir Cmax↔.
Mg once daily didanosine AUC↓ 9% didanosine Cmin ND didanosine Cmax↓ 16% darunavir AUC↔ darunavir Cmin↔ darunavir Cmax↔.
Mg once daily atazanavir AUC↔ atazanavir Cmin↑ 52% atazanavir Cmax↓ 11% darunavir AUC↔ darunavir Cmin↔ darunavir Cmax↔.
Indinavir 800 mg twice daily indinavir AUC↑ 23% indinavir Cmin↑ 125% indinavir Cmax↔ darunavir AUC↑ 24% darunavir Cmin↑ 44% darunavir Cmax↑ 11%.
Boceprevir 800 mg three times daily boceprevir AUC↓ 32% boceprevir Cmin↓ 35% boceprevir Cmax↓ 25% darunavir AUC↓ 44% darunavir Cmin↓ 59% darunavir Cmax↓ 36%.
ANTIBIOTIC Clarithromycin 500 mg twice daily clarithromycin AUC↑ 57% clarithromycin Cmin↑ 174% clarithromycin Cmax↑ 26% darunavir AUC↓ 13% darunavir Cmin↑ 1% darunavir Cmax↓ 17%.
Ethinylestradiol Cmax 14%€ with darunavir/cobicistat ethinylestradiol AUC↓ 44% ethinylestradiol Cmin↓ 62% ethinylestradiol Cmax↓ 32% norethindrone AUC↓ 14% norethindrone Cmin↓ 30% norethindrone Cmax↔ β with darunavir/ritonavir.
Based on published data with darunavir/ritonavir rosuvastatin AUC↑ 93% rosuvastatin Cmax↑ 277% rosuvastatin Cmin ND.
Due to a decrease in the exposure(AUC) of darunavir by 40%, appropriate doses of the combination have not been established.
Based upon not dose normalised values Due to a decrease in the exposure(AUC) of darunavir by 40%, appropriate doses of the combination have not been established.
Mg twice daily maraviroc AUC↑ 305% maraviroc Cmin ND maraviroc Cmax↑ 129% darunavir, ritonavir concentrations were consistent with historical data.
HIV ANTIRETROVIRALS Integrase strand transfer inhibitors Dolutegravir dolutegravir AUC↓ 22% dolutegravir C24h↓38% dolutegravir Cmax↓ 11% darunavir↔*.
There was an increase in tenofovir exposure(AUC and Cmax) of around 40% during co-treatment with Vosevi and darunavir+ ritonavir+ tenofovir disoproxil fumarate/emtricitabine.
Nevirapine 200 mg twice daily nevirapine AUC↑ 27% nevirapine Cmin↑ 47% nevirapine Cmax↑ 18% darunavir: concentrations were consistent with historical data(↑ nevirapine from CYP3A inhibition).
Atorvastatin 10 mg once daily atorvastatin AUC↑ 3-4 fold atorvastatin Cmin↑≈5.5-10 fold atorvastatin Cmax↑≈2 fold darunavir/ritonavir atorvastatin AUC↑ 290% atorvastatin Cmax↑ 319% atorvastatin Cmin ND.
Rosuvastatin 10 mg once daily rosuvastatin AUC↑ 48%║ rosuvastatin Cmax↑ 144%║ based on published data with darunavir/ritonavir.
Ethinylestradiol AUC↓ 44% ethinylestradiol Cmin↓ 62% ethinylestradiol Cmax↓ 32% norethindrone AUC↓ 14% norethindrone Cmin↓ 30% norethindrone Cmax↔ with darunavir/ritonavir.