Примери за използване на Decrease plasma на Английски и техните преводи на Български
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Rifabutin may decrease plasma concentrations of letermovir.
Other inducers of CYP3A4 such as phenobarbital, phenytoin and carbamazepine,may also decrease plasma concentrations of tadalafil.
Ritonavir may decrease plasma concentrations of voriconazole.
Concomitant use of bosentan andsaquinavir/ritonavir may increase plasma levels of bosentan and may decrease plasma levels of saquinavir/ritonavir.
These antivirals may decrease plasma concentration of letermovir.
Co-administration of CRESEMBA with potent CYP3A4/5 inducers such as rifampicin, rifabutin, carbamazepine, long-acting barbiturates(e.g., phenobarbital), phenytoin and St. John's wort, or with moderate CYP3A4/5 inducers such as efavirenz, nafcillin and etravirine, is contraindicated,since these medicinal products can significantly decrease plasma concentrations of isavuconazole(see section 4.3).
Carbamazepine or phenobarbital may decrease plasma concentrations of letermovir.
Medicinal products that may decrease plasma exposure of Vosevi Medicinal products that are strong inducers of P-gp and/or strong inducers of CYP2B6, CYP2C8, or CYP3A4(e.g. carbamazepine, phenobarbital, phenytoin, rifampicin, rifabutin and St. John's wort)may decrease plasma concentrations of sofosbuvir, velpatasvir and/or voxilaprevir leading to reduced therapeutic effect of Vosevi.
CYP3A4 inducers such as rifampin may decrease plasma pazopanib concentrations.
Induction As a moderate inducer of CYP2C9 and a mild inducer of CYP3A4 and glucuronidation,aprepitant can decrease plasma concentrations of substrates eliminated by these routes.
As a mild inducer of CYP2C9, CYP3A4 and glucuronidation,aprepitant can decrease plasma concentrations of substrates eliminated by these routes within two weeks following initiation of treatment.
It is currently unknown whether vemurafenib at a plasma level of 100 µM observed in patients at steady state(approximately 50 µg/ml)may decrease plasma concentrations of concomitantly administered CYP2B6 substrates, such as bupropion.
Co-administration of etravirine with atazanavir/cobicistat ordarunavir/cobicistat may decrease plasma concentrations of the PI and/or cobicistat, which may result in loss of therapeutic effect and development of resistance.
Medicinal products that are strong inducers of P-gp and/or strong inducers of CYP2B6, CYP2C8, or CYP3A4(e.g. carbamazepine, phenobarbital and phenytoin, rifampicin, rifabutin and St. John's wort)may decrease plasma concentrations of sofosbuvir or velpatasvir leading to reduced therapeutic effect of sofosbuvir/velpatasvir.
As a mild inducer of CYP2C9, CYP3A4 and glucuronidation,aprepitant can decrease plasma concentrations of substrates eliminated by these routes.
Concomitant use of etravirine with simeprevir may decrease plasma concentrations of simeprevir.
CYP2B6 induction has not been investigated in vivo andbrivaracetam may decrease plasma concentrations of medicinal products metabolised by CYP2B6(e.g. efavirenz).
Concomitant administration of glecaprevir/pibrentasvir with efavirenz may significantly decrease plasma concentrations of glecaprevir and pibrentasvir, leading to reduced therapeutic effect.
If co-administration cannot be avoided,it needs to be considered that vemurafenib may decrease plasma concentrations of CYP3A4 substrates and thereby their efficacy may be impaired.
Co-administration of bictegravir and medicinal products that potently induce both CYP3A and UGT1A1, such as rifampicin or St. John's wort,may significantly decrease plasma concentrations of bictegravir, which may result in a loss of therapeutic effect of Biktarvy and development of resistance, therefore co-administration is contraindicated(see section 4.3).
A 3-hour hemodialysis session decreases plasma concentrations by approximately 50%.
Multiple dose rifampicin decreases plasma concentrations of letermovir.
Significantly decreased plasma concentrations of simeprevir are expected.
Growth hormone deficiency is associated with decreased plasma and extracellular volumes.
Etravirine without boosted protease inhibitors decreased plasma dolutegravir concentration.
A risk of decreased plasma concentrations resulting in a loss of efficacy could be observed with coadministration of topiramate and St John's Wort.
Carbamazepine decreases plasma concentrations of elvitegravir and cobicistat, which may result in loss of therapeutic effect and development of resistance.
Herbal preparations containing St John's wort(Hypericum perforatum)due to the risk of decreased plasma concentrations and reduced clinical effects of lopinavir and ritonavir(see section 4.5).
Atorvastatin significantly decreased plasma levels of totalC, LDL-C, triglycerides, and apolipoprotein B during the 26 week double-blind phase.
Rifampicin substantially decreases plasma concentrations of atazanavir, which may result in loss of therapeutic effect of EVOTAZ and development of resistance to atazanavir.