Примери за използване на Distribution at steady-state на Английски и техните преводи на Български
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The volume of distribution at steady-state was approximately 39 l/kg.
Fluticasone furoate is widely distributed with volume of distribution at steady-state of, on average, 608 l.
The volume of distribution at steady-state(Vss) varies from 0.7 to 1.4 mL/kg.
After the last 30 mg dose,the median volume of distribution at steady-state was 0.15 l/ kg range.
The volume of distribution at steady-state(Vss) was 2.3 l/kg and systemic clearance was 0.51 l/h/kg.
Following intravenous dosing the volume of distribution at steady-state(Vss) was 31.7 l/kg.
The volume of distribution at steady-state(VSS) determined after intravenous administration was 11 l/kg.
Baseline clearance was 77 ml/ min with a volume of distribution at steady-state(Vss) of 2.6 l; half-life was 55 min.
The volume of distribution at steady-state and clearance were estimated at 1.86 L/m2 and 0.169 L/m2 per day, respectively.
Cemiplimab is primarily distributed in the vascular system with a volume of distribution at steady-state(Vss) is 5.2 l.
The central volume of distribution of etanercept is 7.6 L,while the volume of distribution at steady-state is 10.4 L.
The analogous median apparent volume of distribution at steady-state(Vz/Fss) was also generally consistent and ranged from 43.2 L to 121 L.
Total body oclacitinib clearance from plasma was low- 316 ml/h/kg bodyweight(5.3 ml/min/kg bodyweight),and the apparent volume of distribution at steady-state was 942 ml/kg bodyweight.
Population estimated mean volume of distribution at steady-state(Vss/F) of osimertinib is 918 L indicating extensive distribution into tissue.
Distribution Ivabradine is approximately 70% plasma protein bound and the volume of distribution at steady-state is close to 100 l in patients.
The volume of distribution at steady-state following intravenous administration of 1.0 or 3.0 mg/kg/day is 392±75 and 352±9 ml/kg, respectively.
Abbreviations: Cmax: maximum observed activity; AUC: area under the curve; MRT: mean residence time; CL: clearance;Vss: body weight adjusted volume of distribution at steady-state.
Geometric mean(%CV) clearance was 7.79(25%) L/hr/m2,volume of distribution at steady-state was 834(39%) L/m2, and the elimination half-life was 100(44%) hours.
CI= confidence interval; Cmax= maximum activity; AUC= area under the FVIII activity time curve; t½= terminal half-life; CL= clearance;Vss= volume of distribution at steady-state; MRT= mean residence time.
The mean values of total serum clearance,volume of distribution at steady-state and terminal elimination halflife were 138(± 36) ml/h/kg, 388(± 125) ml/kg and 2.2(± 0.5) h, respectively.
Abbreviations: AUC= area under the factor VIII activity time profile; CL= clearance; t1/2= terminal half-life;Vss= volume of distribution at steady-state; Cmax= maximum factor VIII activity.
In the population pharmacokinetics model, volume of distribution at steady-state was approximately 796 L. Etelcalcetide is predominately bound to plasma albumin by reversible covalent binding.
Abbreviations: AUC= area under the factor VIII activity time profile; t1/2= terminal half-life; MRT= mean residence time; CL= clearance;Vss= volume of distribution at steady-state; IR= Incremental recovery.
The mean(%CV) volume of distribution at steady-state in healthy normal volunteers following 1 mg/kg every 12h is approximately 321 L(6.35), which is greater than total body water.
Peginterferon alfa-2a is found predominantly in the bloodstream andextracellular fluid as seen by the volume of distribution at steady-state(Vd) of 6 to 14 litres in humans after intravenous administration.
After the last 30 mg dose,the median volume of distribution at steady-state was 0.15 l/kg(range: 0.1-0.4 l/kg), indicating that distribution was primarily to the extracellular fluid and plasma compartments.
The disposition of fluticasone propionate is characterised by high plasma clearance(1150 mL/min),a large volume of distribution at steady-state(approximately 300 L) and a terminal half-life of approximately 8 hours.
As a result of tissue binding, the mean apparent volume of distribution at steady-state following a single 5 mg intravenous dose of linagliptin to healthy subjects is approximately 1,110 litres, indicating that linagliptin extensively distributes to the tissues.
Based on population pharmacokinetic analysis, the following mean(percent coefficient of variation) parameters of ipilimumab were obtained: terminal half-life of 15.4 days(34.4%); systemic CL of 16.8 ml/h(38.1%);and volume of distribution at steady-state of 7.47 l(10.1%).