Примери за използване на Heterologous на Английски и техните преводи на Български
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Heterologous booster vaccinations.
Antibody Persistence andBooster Vaccination with Homologous and Heterologous Vaccine Strains.
Heterologous gene expression in industrial hosts E. coli and Bacillus megaterium. Expression vectors.
Vaccination protected animals from lethal challenge with virus homologous and heterologous to the vaccine.
The ability to induce protection against homologous and heterologous vaccine strains was assessed non-clinically using ferret challenge models.
Such studies are not considered meaningful due to the production of antibodies against the heterologous human protein in animals.
The ability to induce protection against homologous and heterologous vaccine strains was assessed non-clinically with A/Indonesia/05/05(H5N1) using ferret challenge models.
Such studies are not considered meaningful due to the production of antibodies against the heterologous human protein in animals.
Of animals challenged with virus heterologous to the vaccine strain after 2 doses of vaccine were protected, and a single dose of heterologous vaccine protected 56% of the animals.
Therefore experimental studies on tumorigenic ormutagenic effects- particularly in heterologous species- are not considered necessary.
Coli is a very versatile host for the production of heterologous proteins, and manifold protein expression systems are available to produce of recombinant proteins in E. coli.
Immunoglobulins are normal constituents of the human body,therefore toxicity testing in heterologous species is of no relevance.
To date a booster vaccination with homologous and heterologous vaccine strains has been administered in the phase 3 study 6 months after primary vaccination with two doses of the A/ Vietnam/ 1203/ 2004 strain vaccine.
SRH results after the first dose,that mimic prepandemic priming plus single heterologous booster dose, met all CHMP criteria.
Heterologous immune response against A/H5N1/Indonesia/5/05(clade 2.1) was detectable in study V87P11 after the second vaccination, indicating cross-reactivity of the clade 2.2 vaccine against clade 2.1 strains.
The Constitutional Court has canceled Law 40, passed in 2004 by the government of Silvio Berlusconi,which banned heterologous artificial insemination.
Unlike heterologous mesotherapy, which uses intradermal implants such as hyaluronic acid, amino acids, vitamins, antioxidants, the revolutionary method of autologous mesotherapy uses the patient's own plasma to release growth factors.
Fenspiride has been shown in the Aptuit study to block hERG channels at supratherapeutic doses in vitro in a heterologous expression system, with an IC50 value of 15.14 µM.
Some heterologous immune response against A/turkey/Turkey/1/2005(NIBRG23; clade 2.2.1) and A/ Indonesia/5/2005(clade 2.1) was detectable both after the second and third vaccinations, indicating cross-reactivity of the clade 1 vaccine against clade 2 strains.
Studies of repeated dose toxicity, genotoxicity, and toxicity to reproduction in animals are impracticable due to induction of andinterference by developing antibodies to heterologous proteins.
Some heterologous immune response against A/H5N1/turkey/Turkey/05(NIBRG23; clade2.2) and A/H5N1/Indonesia(clade 2.1) was detectable both after the second and third vaccinations, indicating cross-reactivity of the clade 1 vaccine against clade 2 strains.
Seroneutralization rates(MN titer≥ 20) at 21 days after a booster vaccination with the 7.5 µg dose ofthe A/Indonesia/05/2005 strain vaccine, tested against both the homologous and heterologous strains, were as follows.
A booster vaccination with a 7.5 µg heterologous A/Indonesia/05/2005 vaccine strain has been administered in a time window of 12 to 24 months after priming vaccination with two doses of the A/Vietnam/1203/2004 strain vaccine in three clinical studies in adults aged 18 to 59 years and in older aged 60 years and above.
Seroneutralisation rates(MN titre> 20) at 21 days after a booster vaccination with the 7.5 µg dose of the A/ Vietnam and A/ Indonesia vaccines,tested against both the homologous and heterologous strains were as follows.
Seroprotection rates(SRH area≥ 25 mm²) at 21 days after a 12 months booster vaccination with the 7.5 µg dose ofthe A/Indonesia/05/2005 strain vaccine, tested against both the homologous and heterologous strains, were as follows.
Specific studies with repeated administration such as reproduction toxicity, chronic toxicity, andcarcinogenicity were not performed with octocog alfa due to the immune response to heterologous proteins in all non-human mammalian species.
Specific studies with repeated administration such as reproduction toxicity, chronic toxicity,and carcinogenicity were not performed with octocog alfa due to the immune response to heterologous proteins in all non-human mammalian species.
Specific studies with long-term repeated administration such as reproduction toxicity, chronic toxicity, andcarcinogenicity were not performed with Nuwiq due to the immune response to heterologous proteins in all non-human mammalian species.
Preclinical studies with repeated dose applications(chronic toxicity, carcinogenicity and mutagenicity)cannot be reasonably performed in conventional animal models due to the development of antibodies following the application of heterologous human proteins.