Примери за използване на Linear clearance на Английски и техните преводи на Български
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Linear clearance was 0.136 L/day for MBC, 0.112 L/day for EBC and 0.176 L/day for.
The mean estimated terminal half-life associated with linear clearance in combination therapy was approximately 15-23 days.
The linear clearance was estimated as a parameter in the population pharmacokinetic analysis and was 9.5 ml/h.
As treatment continues,the impact of this pathway diminishes and the linear clearance pathway predominates.
The linear clearance was estimated as a parameter in the population pharmacokinetic analysis and was 6.25 mL/h.
The total clearance of tocilizumab was concentration-dependent andis the sum of the linear and non-linear clearance.
The linear clearance was estimated as a parameter in the population pharmacokinetic analysis and was 6.7 mL/h in GCA patients.
The total clearance of RoActemra was concentration-dependent andis the sum of the linear and non-linear clearance.
Once the non-linear clearance pathway is saturated,at higher RoActemra concentrations, clearance is mainly determined by the linear clearance.
Based on a population PK analysis, the conjugate(acMMAE) is primarily eliminated by non-specific linear clearance pathway with a value of 0.9 L/day.
Once the nonlinear clearance pathway is saturated,at higher tocilizumab concentrations, clearance is mainly determined by the linear clearance.
The total clearance of tocilizumab was concentration-dependent andis the sum of the linear clearance and the nonlinear clearance. .
Linear clearance observed in the dose range of 2 to 9 mg/kg is likely due to non saturable biological mechanisms of elimination such as protein catabolism.
The pharmacokinetics of RoActemra is characterized by nonlinear elimination which is a combination of linear clearance and Michaelis-Menten elimination.
The linear clearance was estimated as a parameter in the population pharmacokinetic analysis and was 5.7 mL/h in paediatric patients with systemic juvenile idiopathic arthritis.
Obinutuzumab elimination comprises two parallel pathways which describe clearance, a linear clearance pathway and a non-linear clearance pathway which changes as a function of time.
These observations suggest CD38 may become saturated at higher doses, after which the impact of target binding clearance is minimised andthe clearance of daratumumab approximates the linear clearance of endogenous IgG1.
Population pharmacokinetic analysis for pJIA patients showed body size related impact on linear clearance so that body-weight based dosing should be taken into consideration(see Table 9).
At high serum concentrations, when total clearance of RoActemra is dominated by linear clearance, an effective t½ of approximately 32 days was derived from the population parameter estimates.
As reslizumab binds to a soluble target, linear non-target-mediated clearance is expected.
X, Y Taiwan Hiwin high-precision,zero clearance increased linear guide+rack.
Transmission system X, Y Taiwan AMT high-precision,zero clearance increased linear guide+ rack.
X, Y Taiwan AMT high-precision,zero clearance increased linear guide+ rack Z the arc voltage control.
Inotuzumab ozogamicin pharmacokinetics were well characterised by a 2-compartment model with linear and time-dependent clearance components.
Clearance of cemiplimab is linear at doses of 1 mg/kg to 10 mg/kg every two weeks.
The pharmacokinetics of topiramate in children, as in adults receiving add-on therapy,are linear, with clearance independent of dose and steady-state plasma concentrations increasing in proportion to dose.
A population pharmacokinetic evaluation of Oncaspar based on data obtained from Studies AALL07P4(IV), DFCI 11-001(IV), and CCG-1962(IM)identified that clearance(linear and saturable) increased approximately proportional to BSA and volume of distribution increased slightly more proportional to BSA.
The pharmacokinetic profile of topiramate compared to other antiepileptic drugs shows a long plasma halflife, linear pharmacokinetics, predominantly renal clearance, absence of significant protein binding, and lack of clinically relevant active metabolites.
There is a linear relationship between body weight and estimated thalidomide clearance; in multiple myeloma patients with body weight from 47-133 kg, thalidomide clearance ranged from approximately 6-12 L/h, representing an increase in thalidomide clearance of 0.621 L/h per 10 kg body weight increase.
The pharmacokinetics of laropiprant are linear, displaying approximately dose-proportional increases in AUC and Cmax and no evidence of time-dependent clearance.