Примери за използване на Mainly metabolised на Английски и техните преводи на Български
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Fluvastatin is mainly metabolised in the liver.
Ketek may produce a similar interaction with lovastatin andatorvastatin which are also mainly metabolised by CYP3A4.
Ketoconazole is mainly metabolised through CYP3A4.
Thus, interactions can arise when coadministering high doses of eslicarbazepine acetate with medicinal products that are mainly metabolised by CYP2C19.
Imatinib is mainly metabolised through the liver.
Based on preclinical data andthe human mass balance study, cobimetinib is mainly metabolised, with minimal renal elimination.
Ketoconazole is mainly metabolised by cytochrome CYP3A4.
Thus, interactions can arise when co-administering high doses of eslicarbazepine acetate with medicinal products that are mainly metabolised by CYP2C19(e.g. Phenytoin).
Irbesartan is mainly metabolised by CYP2C9 and to a lesser.
Hepatic insufficiency: Imatinib is mainly metabolised through the liver.
Granisetron is mainly metabolised to 7-hydroxygranisetron and 9'N-desmethylgranisetron.
In vitro andin vivo data indicate that lumacaftor is mainly metabolised via oxidation and glucuronidation.
Piperaquine was mainly metabolised by CYP3A4 and to a lesser extent by CYP2C9 and CYP2C19.
Although specific studies have not been performed,co-administration of Invirase/ ritonavir with medicinal products that are mainly metabolised by CYP3A4 pathway may result in elevated plasma concentrations of these medicinal products.
Irbesartan is mainly metabolised by CYP2C9 and to a lesser extent by glucuronidation.
In vitro studies have shown that cabazitaxel is mainly metabolised through CYP3A(80% to 90%)(see section 5.2).
Sufentanil is mainly metabolised in humans by the cytochrome P450-3A4 enzyme system(see section 4.5).
Thus, an increase in the dose of the medicinal products that are mainly metabolised through CYP3A4 may be required, when used concomitantly with Exalief.
Nilotinib is mainly metabolised in the liver with CYP3A4 expected to be the main contributor to the oxidative metabolism.
Substances that may increase nilotinib serum concentrations Nilotinib is mainly metabolised in the liver and is also a substrate for the multi-drug efflux pump, P- glycoprotein(Pgp).
Nilotinib is mainly metabolised in the liver and is also a substrate for the multi-drug efflux pump, P-glycoprotein(P-gp).
Interferon beta-1a is mainly metabolised and excreted by the liver and the kidneys.
Cilostazol is mainly metabolised by CYP3A4, and CYP2C19 and has two main active metabolites, OPC13015(dehydrocilostazol, 3-7 times more potent than cilostazol), and OPC-13213(trans-hydroxycilostazol, 2- 5 times less potent than cilostazol).
Ruxolitinib is mainly metabolised by CYP3A4(> 50%), with additional contribution from CYP2C9.
Palonosetron is mainly metabolised by CYP2D6, with minor contribution by CYP3A4 and CYP1A2 isoenzymes.
Palonosetron is mainly metabolised by CYP2D6, with minor contribution by CYP3A4 and CYP1A2 isoenzymes.
Lesinurad is mainly metabolised by CYP2C9 and mEH, and to a lesser extent by CYP1A1, CYP2C19 and CYP3A.
Sufentanil is mainly metabolised in humans by the cytochrome P450-3A4 enzyme system(see section 4.5).
Since mitotane is mainly metabolised through the liver, mitotane plasma levels are expected to increase if liver function is impaired.
Since dasatinib is mainly metabolised through the liver, exposure to dasatinib is expected to increase if liver function is impaired.