Примери за използване на Therapeutic index на Английски и техните преводи на Български
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Fampridine has a narrow therapeutic index.
Therapeutic index is a measure of the safety of the drug.
Drugs with a narrow therapeutic index.
The therapeutic index of a drug is a measure of a drug's safety.
Compounds with narrow therapeutic index.
If a narrow therapeutic index P-gp or BCRP substrate must be used, it should be used with caution.
Medications with a narrow therapeutic index.
In addition, testosterone has a therapeutic index of 1 meaning there is similarity in the proportion between the anabolic and androgenic effects.
Paracetamol has a very low Therapeutic index.
Co-administration of narrow therapeutic index P-gp, or BCRP substrates(e.g., digoxin, dabigatran, everolimus, sirolimus) with venetoclax should be avoided.
Some drugs have a narrow therapeutic index.
As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril hydrochloride and spironolactone.
Interaction with CYP1A2 substrates with narrow therapeutic index.
Caution is advised if Zydelig is used together with narrow therapeutic index drugs that are substrates of these enzymes(warfarin, phenytoin, S-mephenytoin).
It also showed that dexamethasone had a broad therapeutic index.
As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril(hydrochloride) and spironolactone.
In addition, letrozole is not considered to have a narrow therapeutic index.
When co-administering medicinal products metabolized by CYP1A2,particularly medicines which have a narrow therapeutic index(e.g., tizanidine, theophylline), dose adjustments may be considered based on appropriate clinical monitoring.
Ciclosporin is considered a‘critical dose drug' with narrow therapeutic index.
These symptoms are attributable to the low therapeutic index of carisoprodol.
Sonata did not affect the pharmacokinetic and pharmacodynamic profiles of digoxin and warfarin,two compounds with a narrow therapeutic index.
This is clinically relevant for CYP450 substrates with a narrow therapeutic index, where the dose is individually adjusted(e.g. warfarin).
Caution is recommended in case of concomitant use with sensitive CYP3A4 substrates with a narrow therapeutic index(see section 4.4).
Caution should be exercised when prescribing medicinal products with a narrow therapeutic index that require absorption in the intestinal tract.
If applicable, the effective andnontoxic dose findings in the same animal species should be compared(i.e., the therapeutic index should be discussed).
Caution is advised if Zydelig is used together with narrow therapeutic index drugs that are substrates of CYP2C8(paclitaxel).
Co-administration with medicinal products with narrow therapeutic index(see section 4.5).
Therefore, appropriate clinical and/or laboratory monitoring is recommended when giving narrow therapeutic index P-gp dependent medicinal products like digoxin concomitantly with ticagrelor.
However, no dosage adjustment is necessary because of the wide therapeutic index of aciclovir.
Caution should be exercised when Parareg isadministered with individually titrated, narrow therapeutic index medications that are predominantly metabolised by CYP2D6.