Примери коришћења Muscarinic на Енглеском и њихови преводи на Српски
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It has similar affinity to the subtypes of muscarinic receptors, M1 to M5.
Nicotinic and muscarinic are two main kinds of"cholinergic" receptors.
Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors.
Muscarinic receptors are so named because they are more sensitive to muscarine than to nicotine.
The postganglionic neuron then releases ACh to stimulate the muscarinic receptors of the target organ.
Muscarinic acetylcholine receptors possess a regulatory effect on dopaminergic neurotransmission.
Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5.
Muscarinic receptors are used in the following roles: ACh is always used as the transmitter within the autonomic ganglion.
During research the affinity of both drugs with benzodiazepine and cholinergic muscarinic receptors been identified.
Muscarinic acetylcholine receptors are also present and distributed throughout the local nervous system, in post-synaptic and pre-synaptic positions.
Molecular biology has shown that the nicotinic and muscarinic receptors belong to distinct protein superfamilies.
The side effects of pyridostigmine bromide are most commonly related to overdosage andgenerally are of two varieties, muscarinic and nicotinic.
For example, the drug pirenzepine is a muscarinic antagonist(decreases the effect of ACh), which is much more potent at M1 receptors than it is at other subtypes.
Anticholinergics are classified according to the receptors that are affected:Antimuscarinic agents operate on the muscarinic acetylcholine receptors.
M2 muscarinic receptors act via a Gi type receptor, which causes a decrease in cAMP in the cell, generally leading to inhibitory-type effects.
For example, atropine from deadly nightshade( Atropa belladonna)that functions as a competitive antagonist of the muscarinic acetylcholine receptors.
They may also antagonise muscarinic acetylcholine receptors, causing symptoms such as dry mouth, urinary retention and confusion in the elderly.
Revival of acetylcholinesterase with pralidoxime chloride works more effectively on nicotinic receptors while blocking acetylcholine receptors with atropine is more effective on muscarinic receptors.
The development of a muscarinic antagonist based on himbacine failed but an analog, vorapaxar, has been approved by the FDA as a thrombin receptor antagonist.
Neurotoxicity can also result from the inhibition of receptors; for example, atropine from deadly nightshade(Atropa belladonna)that functions as a competitive antagonist of the muscarinic acetylcholine receptors.
It is used mainly for mapping the distribution of M2 and M4 muscarinic receptors in the brain, and studying their involvement in the development and treatment of dementia and schizophrenia.
However, the subsequent hyperpolarization(IPSP) and slow depolarization(Slow EPSP)that represent the recovery of the postganglionic neuron from stimulation are actually mediated by muscarinic receptors, types M2 and M1 respectively(discussed below).
Himbacine's activity as a muscarinic receptor antagonist,with specificity for the muscarinic acetylcholine receptor M2, made it a promising starting point in Alzheimer's disease research.