In 29 patients and 37 family members in the United States, the Cw7 and DR4 types were significantly more prevalent in Caucasians with single-bone lesions.
Pretest and posttest discussions can include the possibility of medical, psychological,and social impact on family members and strategies on how to lessen any negative impact.
The explanation for these differences lies in the method of identifying the individuals tested,with penetrance estimates increasing with the number of affected family members.
This pedigree shows some of the classic features of a family with Lynch syndrome,including affected family members with colon cancer or endometrial cancer, a young age at onset in some individuals, and incomplete penetrance.
Problems that may be encountered in eliciting a family history and constructing a pedigree include difficulty contacting relatives with whom one has little or no relationship,differing views between family members about the value of genetic information, resistance to discussion of cancer and cancer-related illness, unanticipated discovery of previously unknown medical or family information, and coercion of one relative by another regarding testing decisions.
家系員に対するリスクおよび遺伝情報の浸透。
Dissemination of risk and genetic information to family members.
患者と罹患家系員の両者が患者である。
Both the patient and the affected family member are patients.
これらの組織は家系員が遺伝情報を開示するよう推奨している。
These organizations recommend that family members disclose genetic information.
人の家系員が50歳前に大腸がんと診断されている。
One family member diagnosed with CRC before age 50 years.
これらのがんと他のがんに罹患した複数の家系員がいること;。
Multiple family members affected with these and other cancers;
前立腺がんの男性および非罹患男性家系員[22]前立腺がん男性559人;。
Males with prostate cancer and their unaffected male family members[22] 559 men with prostate cancer;
どちらが優先されるか-患者の知る権利か、それとも家系員の自律性か。
What takes precedence- the patient's right to know or the family member's autonomy?
疾患との関係が不明の多様体の意味を明らかにするため、他の家系員を評価する必要が生じる。
Need to evaluate other family members to determine the significance of variants not known to be disease related.
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