The incidence and severity of AEs were similar in the two treatment groups,although immune-related AEs occurred more frequently in the experimental arm, which also applied to treatment discontinuations.
染色体異常試験被験物質に染色体異常を引き起こす働きがあるか、培養した細胞を用いて調べる試験です。
Chromosomal disorder test/Neurovirulence test This test uses cultured cells to check for any property of the test substance that may cause chromosomal disorder.
The reaction between the test sample and the anti-IL-13 antibody is performed at 10-30° C.(preferably 15-25° C.) for 60-180 minutes(preferably 90-120 minutes).
After doing the tape stripping, test substances were applied to the inner side of the forearm every morning and every evening(twice a day) for 5 days, and the transepidermal water loss(TEWL) and the moisture content of stratum corneum were measured.
According to the protocol, magnetic resonance imaging( MRI) data will be collected in a subgroup of subjects at week 52 and at additional time points,and radiographs will be taken on all study patients at week 104 and at additional time points.
Evaluation of the moisture content ofstratum corneum After doing the tape stripping, test substances were applied to the inner side of the forearm every morning and every evening(twice a day) for 5 days, and the transepidermal water loss(TEWL) and the moisture content of stratum corneum were measured.
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