They also block the growth of human breast tumors in mouse models.”.研究人员在MPSIIIB小鼠模型上测试了他们的方法。
The researchers tested their approach on a mouse model of MPS IIIB.它的平台Kymouse使用小鼠模型发现并生产单克隆抗体。
Its platform, Kymouse, uses murine models to discover and produce monoclonal antibodies.
How is the mouse model used to study human diseases?
The studies on the mouse model put the researchers on the right track.Combinations with other parts of speech
It is possible to test new medications for tremor in mouse models.
Fragile X:New drug strategy corrects behavior/biochemical measures in mouse model.Celis和苏丹都希望他们在癌症小鼠模型中的观察能够找到进入人类癌症患者临床研究的途径。
Both Celis and Sultan hope their observations in mouse models of cancer can find their way into clinical studies with human cancer patients.他们证明,在糖尿病小鼠模型中,iBRD9使葡萄糖水平回落到正常范围。
They demonstrated that, in a mouse model of diabetes, iBRD9 brought glucose levels back down into the normal range.他们再次发现这在小鼠模型和糖尿病猴子中确实是可行的。
Once again, they found that it was, indeed, possible in mouse models- and also in diabetic monkeys.研究小组在人类细胞培养和小鼠模型中测试ADC,发现其成功杀死癌症细胞,且“无可辨别的毒性”。
The team tested the ADC in human cell cultures and mouse models and found that it successfully killed off cancer cells"with no discernible toxicities.".在小鼠模型中,毒素显着增加疾病并刺激免疫反应,这使脓毒性感染恶化。
In a mouse model, the toxin significantly increased disease and stimulated the immune response, which worsened the septic infection.我们发现两种经过FDA批准的药物可以纠正HHT小鼠模型中的分子缺陷和相关的AVM,”Marambaud说。
We found that a combination of two FDA-approved drugs correct the molecular defects andassociated AVMs in HHT mouse models," Marambaud said.使用小鼠模型的体内实验显示cis-WOOH充当一种信号分子,诱导动脉松弛和降低血压。
In vivo experiments using a mouse model showed that cis-WOOH acts as a signaling molecule, inducing arterial relaxation and decreasing blood pressure.他说,特别是,阿尔茨海默病小鼠模型中死亡的神经元数量远低于人类。
In particular, the number of neurons that die in mouse models of Alzheimer's disease is far lower than in humans.在使用胶质母细胞瘤小鼠模型的早期研究中,研究人员表明,寨卡病毒可以在实验室中攻击GSC。
In earlier studies using a mouse model of glioblastoma, researchers showed that the Zika virus can attack GSCs in the laboratory.因此,他们采取了乳腺癌的小鼠模型,给他们化疗,并开始在他们的骨髓中寻找休眠细胞。
So they took mouse models of breast cancer, gave them chemotherapy, and started searching for dormant cells in their bone marrow.这项研究以小鼠模型进行,测试了动物能够如何快速适应他们的行为。
The study, conducted in a mouse model, tested how quickly the animals would be able to adapt their behavior to a given situation.通过使用小鼠模型,我们已经确定基因H19在棕色脂肪细胞中执行一种形式的基因控制。
By using mouse models, we have identified that the gene H19 performs a form of gene control in brown fat cells.利用小鼠模型,一项新研究探究了大脑如何控制食欲,以及食欲与积极和消极情绪之间的联系。
Using a mouse model, new research examines how the brain controls the appetite, as well as the link between appetite and positive and negative emotions.很多实验室均通过小鼠模型验证了这一猜想,并最终促成了CTLA-4阻断抗体ipilimumab的问世。
Many laboratories have validated this conjecture through a mouse model and eventually contributed to the advent of the CTLA-4 blocking antibody ipilimumab.在小鼠模型中,研究人员能够直接探索香烟烟雾暴露,NLRX1和MAVS/RIG样解旋酶途径之间的关系。
In mouse models the researchers were able to explore directly the relationship between cigarette smoke exposure, NLRX1, and the MAVS/RIG-like helicase pathway.利用小鼠模型,谢和团队测试了SCNPs作为潜在的癌症治疗方法,将SCNPs注入肿瘤中。
Using a mouse model, Xie and the team tested SCNPs as a potential cancer therapeutic, injecting SCNPs into tumors.在癌细胞系和小鼠模型中,它降解了一种名为EZH2的蛋白质,该蛋白质驱动三阴性乳腺癌的生长。
In a cancer cell line and mouse models, it degraded a protein called EZH2 that drives the growth of triple-negative breast cancer.因此,在小鼠模型中增加TREM2水平改善了几个让人想起在患者身上发现的特征,”Yang说。
Thus, increasing TREM2 levels in the mouse model improved several characteristics that are reminiscent of those found in patients,” Yang said.研究人员设计了小鼠模型,因为它们是药物开发的重要组成部分,通常是实验室实验后的第一步。
The investigators designed mouse models because they are an essential part of drug development, often the first step after laboratory experiments.为了确定TSP2是否有助于延迟伤口愈合,我们从糖尿病小鼠模型中遗传性地去除了TSP2并观察到伤口愈合得到改善。
To determine whether TSP2 contributes to delayed wound healing,we genetically removed TSP2 from a mouse model of diabetes and observed improved wound healing.使用APS的小鼠模型,研究小组首先管理CGS21680并发现它降低了血液中NETs的水平。
Using mouse models with APS, the research team first administered CGS21680 and found that it reduced the levels of NETs in their blood.在使用小鼠模型的进一步实验中,研究人员发现植物提取物能够减少舌癌的发生。
In further experiments using mouse models, the researchers found that the plant extract was able to reduce the incidence of tongue cancer.