Gap 26 is a connexin mimetic peptide, corresponding to residues 63-75 of connexin 43, which is a gap junction blocker.
挑战在于DNA仅包含有关蛋白质构建块序列的信息,称为氨基酸残基,形成长链。
The challenge is that DNA only contains information about the sequence of a protein'sbuilding blocks called amino acid residues, which form long chains.
硬蛋白的肽序列通常只有有限的重复残基;后者可以构造出不同寻常的二级结构,例如胶原螺旋。
A scleroprotein's peptide sequence often has limited residues with repeats; these can form unusual secondary structures, such as a collagen helix.
TFIIIA的氨基酸测序揭示了9个30个氨基酸的串联序列,包括两个不变对的半胱氨酸和组氨酸残基。
Amino acid sequencing of TFIIIA revealed nine tandem sequences of 30 amino acids,including two invariant pairs of cysteine and histidine residues.
此外,结构首次阐明多个Aβ蛋白质分子中全部的42个氨基酸残基的位置和构象。
Furthermore, the structure elucidates the location andconformation of all 42 amino acid residues of the many individual Aβ protein molecules for the first time.
的氨基酸残基的β桶内部的填充物是极其稳定的,这会导致一个非常高的荧光量子产率(高达80%)。
The packing of amino acid residues inside the beta barrel is extremely stable, which results in a very high fluorescence quantum yield(up to 80 percent).
因此,怀疑HIF-1α中脯氨酸残基的氧依赖性羟基化可能赋予了允许VHL结合所需的构象变化。
Thus, it was suspected that oxygen-dependent hydroxylation of proline residues in HIF-1a might confer the conformational change required to allow VHL binding.
引入多样性的另一种方法涉及HVR定向的方法,其中几个HVR残基(例如一次4-6个残基)被随机化。
Another method to introduce diversity involves HVR-directed approaches, in which several HVR residues(e.g., 4-6 residues at a time) are randomized.
These monoenzymes, which include the sirtuins and many of the PARP(ARTD) and ART proteins,transfer a single ADP-ribose unit to the target residue(MARylation).
这些残基,其显示为在电子透射显微照片“模糊外衣”,表现出对多肽链的两端越来越大的振幅运动。
These residues, which appear as a“fuzzy coat” in transmission electron micrographs, exhibit increasingly larger-amplitude motion towards the two ends of the polypeptide chain.
线性B细胞表位(a)由连续/连续残基组成,而构象B细胞表位(b)沿序列包含分散/不连续残基。
Linear B-cell epitopes(a) are composed of sequential/continuous residues, while conformational B-cell epitopes(b) contain scattered/discontinuous residues along the sequence.
然而,当将烃基残基描述为取代的时,其可以可选地包含除了取代基残基的碳和氢成员之外的杂原子。
However, when the hydrocarbyl residue is specifically described as substituted, it can contain heteroatoms other than the carbon and hydrogen members of the substituent residue.
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