Pancreatic ductal adenocarcinoma(PDAC)may be treatable using newly-developed small molecules that show high antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.
靶向P300/CBPCH1区域的小分子抑制剂能够抑制前列腺癌的生长.
Small molecule inhibitors targeting the CH1 region of P300/CBP can inhibit the growth of prostate cancer.
Arvinas is developing new small molecules‒ known as PROTACs(PROteolysis TArgeting Chimeras)‒ aimed at degrading disease-causing cellular proteins via proteolysis.
另一个项目是开发cGAS的小分子抑制剂,旨在阻断信号通路更上游的节点。
The second program is aiming to develop small-molecule inhibitors of cGAS, which will block the pathway at a more upstream node.
在竞争资源时,细菌产生的小分子改变了单独培养时存在的模式的抗生素产生,Straight说。
In competition for resources, the bacteria produced small molecules that alter antibiotic production from patterns present when cultured separately, Straight said.
在尝试中hedgehog(Hh)途径的小分子激动剂用于重现这些研究结果通过静脉给药。
Small-molecule agonists of the hedgehog(Hh) pathway were used in an attempt to reproduce these findings through intravenous administration.
作为一个结构简单的小分子,很可能白藜芦醇在整个身体中具有非特异性的相互作用,特别是在较高的剂量下。
As a small molecule with a simple structure, it is likely resveratrol has non-specific interactions throughout the body, especially at higher doses.
它允许Algomedix从具有最大优化潜力的小分子开始,实现小分子药物的复杂需求。
It allows Algomedix to start with small molecules that have the greatest potential for optimization to achieve the complex requirements of a small molecule drug.
另一个项目是开发cGAS的小分子抑制剂,旨在阻断信号通路更上游的节点。
The second program is designed to develop small-molecule inhibitors of cGAS, which will block the pathway further upstream.
目前,有几种临床可用的小分子抑制剂和针对特定RTK的单克隆抗体。
Currently, there are several clinically available small molecule inhibitors and monoclonal antibodies against specific RTKs.
Small-molecule inhibitors of cytochrome c/IP3R interactions may prove useful in treating disorders associated with inappropriate intrinsic and extrinsic apoptotic signaling.
他们在你的血管中寻找对死亡有预测作用的小分子,”陈说道,他的公司也投资了这家公司。
They look for small molecules in your blood stream that are predictive of mortality," said Chen, whose firm has invested in the company.
研究人员找到了一种重要的小分子,它在禁食或卡路里限制条件下产生。
Researchers identified an important small molecule that is produced during fasting or calorie restriction conditions.
SW033291 is a small-molecule inhibitor of 15-PGDH(Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
我们开发和使用获得专利的AI技术,以帮助公司和大学发现和开发可改善人类健康和农业生产力的小分子。
We develop and use patented AI technology to help companies and universities discover anddevelop small molecules to improve human health and agricultural productivity.
也许最令人兴奋的是,这项工作开辟了一个可操作的路线图,能够以一般和自动化的方式制造大多数的小分子。
Perhaps most exciting, this work has opened up an actionable roadmap to a general andautomated way to make most small molecules.
我们发现了一种新的小分子,它可以针对植物生长所需的酶的保守催化位点。
We identified a new small molecule that could target the conserved catalytic site of an enzyme that is required for plant growth.”.
因为PAK的失调与各种人类疾病密切相关,所以这些激酶的小分子抑制剂作为治疗剂具有很大的潜力。
Because the deregulation of PAKs isclosely associated with various human diseases, small-molecule inhibitors of these kinases have great potential as therapeutic agents.
表面抗原(称为HBsAg)是涉及病毒进入肝细胞的小分子。
Surface antigens(called HBsAg) are small molecules involved in virus entry into liver cells.
研究人员发现,如果一个被称为EPPS的小分子是添加到Aβ浓度一定的溶液中,这些分子会迫使它们分开。
The researchers found that if a small molecule known as EPPS was added to a solution holding Aβ concentrations, the molecule would force them apart.
科学家发现了一组大学生运动员血浆里的六个特定的小分子,已诊断出这些运动员有脑震荡。
Six specific small molecules from blood plasma were discovered in a group of college athletes who had been diagnosed with concussions.
Here, they identified a small molecule, SMARt-420, that interacts with a secondary gene, which in turn stimulates expression of EthA.
拥有这种蛋白质的原子分辨率结构正是药物化学家和制药科学家需要开始设计的小分子,可以阻止它。
Having the atomic-resolution structure for this protein is exactly what medicinal chemists andpharmaceutical scientists need to start designing small molecules that can block it.”.
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