Cedilla正在使用更传统的小分子药物在泛素化过程之前使致病蛋白质不稳定。
In short, Cedilla is using more traditional small molecule drugs to destabilize disease-causing proteins ahead of the ubiquitination process.相反,由化学基化合物组成的小分子药物可以容易地复制并且再生成本相当低。
In contrast, small molecule drugs made up of a chemically based compound can be easily replicated and are considerably less expensive to reproduce.通过使用抑制这一过程的小分子药物,他们能够关闭REST,并且部分地恢复这些小鼠的听力。
Using small-molecule drugs that inhibit this process, the investigators were able to turn off REST and partially restore hearing.不同于像阿司匹林和醋氨酚这样的小分子药物,许多复杂的药物是重组蛋白,是通过生物。
Unlike small molecule drugs like aspirin and acetaminophen, many complex drugs are recombinant proteins and are made via bioprocessing.一些靶向蛋白酶的小分子药物已经上市,而更多的药物则处于开发之中。
Several small-molecule drugs targeting proteases are already on the market and many more are in development.Combinations with other parts of speech
Ribometrix是一家平台治疗公司,研发针对功能性3DRNA结构治疗人类疾病的小分子药物。
Ribometrix is a platform therapeutics company discovering small molecule drugs that target functional 3D RNA structures to treat human diseases.VertexPharmaceuticalsIncorporated(纳斯达克股票代码:VRTX)致力于发现,开发,生产和商业化用于治疗严重疾病的小分子药物。
Vertex Pharmaceuticals Incorporated(Vertex) is engaged in the business of discovering,developing and commercializing small molecule drugs for the treatment of serious diseases.一直以来都没有办法生成能够抑制WT1功能的小分子药物。
There has not been a way to make small molecule drugs that can inhibit WT1 function.基于RNA环的新基因治疗方法可允许RNA转录物的表达由人工植入的小分子药物控制。
A new gene therapy approach based on RNA circuits may allow theexpression of RNA transcripts to be controlled by small molecule drugs.AthiraPharma的小分子药物NDX-1017旨在恢复大脑中失去的或建立新的连接。
Athira Pharma's small molecule drug NDX-1017 designed to‘restore lost or build new connections in the brain.'.Cytokinetics正在开发主要用于增加肌肉功能和收缩性的小分子候选药物。
Cytokinetics is developing small molecule drug candidates specifically engineered to impact muscle function and contractility.这一资助将帮助Kineta公司将两种候选的小分子药物向临床试验迈出了一步。
The funds will help Kineta move two small-molecule drug candidates closer to clinical trials.各大公司的小分子药物发现研究目前平均外包渗透率估计为40%。
The current average outsourcing penetration of small molecule drug discovery research among major companies is estimated at 40 percent.CarthroniX的联合创始人兼首席执行官VanHandel描述了他们发现的能够激活患者干细胞的小分子药物。
Van Handel, co-founder and CEO of CarthroniX, described their discovery of small molecule drugs capable of activating patients' stem cells.他们发现,一类癌症"干细胞样"细胞对一类抑制JAK/STAT通路的小分子药物敏感。
They showed that a subpopulation ofcancer‘stem-like' cells is sensitive to a class of small molecule drugs that inhibit the JAK/STAT pathway.在人类细胞中,Kay的突破性研究已经导致了针对特定时钟蛋白的小分子药物的发现。
In human cells,Kay's break-through research has led to the discovery of small molecule drugs targeting specific clock proteins.为什么怀疑?这位斯克里普斯研究所(ScrippsResearchInstituteFlorida)的化学家一直试图做一些违反药物发现教条的事情:发明可以靶向RNA的小分子药物。
The Scripps Research Institute Florida chemist has been trying to do something that defies drug discovery dogma:Invent small-molecule drugs that can target RNA.
A good small-molecule drug typically has a mass of less than 500 daltons.临床专攻:靶向目前难于成药的RNA靶点的小分子药物. 传统的小分子药物和天然产物来源的营养保健品的药理学也在积极研究。
The pharmacology of traditional small-molecule drugs and natural product-derived nutraceuticals are also actively investigated.AthiraPharma的小分子药物NDX-1017旨在“恢复大脑中失去的连接或建立新的连接”。
M3 Biotechnology's small molecule drug NDX-1017 designed to‘restore lost or build new connections in the brain.'.年,我们投资了5000万美元,在无锡生产基地附近建立新的小分子药物开发和生产基地。
In 2015,$50 million was invested to set up the new small molecule drug development and production base nearby to the Wuxi Production Base.批准用于其他人类疾病的小分子药物可能会调节2019-nCoV的病毒-宿主相互作用。
Small-molecule agents approved for other human diseases may modulate the virus- host interactions of 2019-nCoV.研究人员与研究快速分裂肿瘤细胞的同事合作,筛选出80种针对细胞代谢而不是病毒的小分子和药物。
Working with colleagues who study rapidly dividing tumor cells,the researchers screened 80 small molecules and drugs that targeted cell metabolism rather than the virus.该ANC的设计理念可以推广至更多具有治疗潜力的气体小分子药物的研发中。
The design concept of the ANCcan be extended to the development of more gas small molecule drugs with therapeutic potential.它允许Algomedix从具有最大优化潜力的小分子开始,实现小分子药物的复杂需求。
It allows Algomedix to start with small molecules that have the greatest potential for optimization to achieve the complex requirements of a small molecule drug.旨在补偿CFTR基因的各种突变的许多小分子药物正在开发中。
A number of small molecules that aim at compensating various mutations of the CFTR gene are under development.