Reh said that at first they thought another transcription factor was involved.发现阿司匹林降低了一种叫TIF-IA的转录因子的活性。
They found that aspirin reduced the activity of a transcription factor called TIF-IA.研究人员还确定了受CYC065影响的特定转录因子。
Researchers also identified specific transcription factors that were impacted by CYC065.
DNA damage signals cause activation of the transcription factor p53.Combinations with other parts of speech
Richard Mann- Role of transcription factors in development.
They note that the survival of senescent cells depends on the transcription factor FOXO4.而不是RTK基因,新的研究发现三个转录因子负责胶质母细胞瘤:Sox2,Olig2和Zeb1。
Instead of the RTK genes, the new study found three transcription factors to be responsible for glioblastoma: Sox2, Olig2, and Zeb1.转录因子HIF也特别能够帮助T细胞适应肿瘤的缺氧微环境。
Transcription factor HIF is also especially able to help the T cells to adapt to the tumour's anoxic micro-environment.这种转换通过称为PPAR的转录因子的激活而发生,其开启了参与代谢脂肪酸的许多基因。
This switch occurs through the activation of transcription factors called PPARs, which turn on many genes that are involved in metabolising fatty acids.该模型使用大规模染色质分析数据,包括转录因子结合、DNase-I敏感性和组蛋白标记谱,来预测非编码变异的功能后果。
The model uses large-scale chromatin-profiling data, including transcription factor binding, DNase I sensitivity and histone-mark profiles to predict the functional consequences of a non-coding variant.主转录因子以非常高的水平表达并主导转录机制,因为存在很多这些因子。
The master transcription factors are expressed at very high levels and dominate the transcription machinery because there is so much of these factors.".PLX-200也激活PPARα,增强脑细胞中转录因子EB(TFEB)的水平。
PLX-200 also activates PPARα, which enhances production of transcription factor EB(TFEB) in brain cells.先前的研究还表明,SMAD3可能与数百种不同的转录因子相互作用,以达到对环境输入的理想反应。
Previous research had also suggested thatSMAD3 might interact with hundreds of different transcription factors to achieve the desired response to environmental input.确定RPC子细胞命运的线索由多个转录因子家族编码,包括bHLH和同源域因子。
The cues that determine a RPC daughtercell fate are coded by multiple transcription factor families including the bHLH and homeodomain factors..然而,与eb病毒感染相关的特定转录因子的突破性鉴定开辟了新的研究路线,可以加速寻找治疗的努力。
However, the breakthrough identification of specific transcription factors connected to EBV infections opens new lines of study that could accelerate efforts to find cures.信号转导和转录激活因子3(STAT3)是一种转录因子,参与多种癌症细胞生理活动的调控,包括宫颈癌。
Signal transducer and activator of transcription 3(STAT3) is a transcription factor which regulates a variety of cancer cellular physiological activities including cervical cancer.通过Ras-Erk控制的两个转录因子似乎是这些影响的关键介质:Pnt,基因表达活化因子,以及Aop,抑制因子。
Two transcription factors controlled by Ras-Erk appear to be key mediators of these effects: Pnt, a gene expression activator, and Aop, a repressor.如果使用本次网络研讨会介绍的方法,转录因子ChIP-seq测序正常情况下的结合位点数量在一千到几千之间。
If you use the method in this webinar the number we normally get from transcription factor ChIP-seq is around 1,000 to several thousand.此外,研究人员还发现Id1能够抑制另一个转录因子Ebf2,后者通常有助于白色脂肪转变为褐色脂肪。
Additionally, the researchers found that Id1 inhibits another transcription factor, Ebf2, which usually helps white fat turn into beige.柳还解释了microRNAs,而非转录因子,才是将人体皮肤细胞直接重新编程转化为神经元的重要组成部分。
Yoo also explained that the microRNAs, but not the transcription factors, are important components for the general reprogramming of human skin cells directly to neurons.L6细胞中的乳酸敏感转录因子网络:MCT1的激活和线粒体的生物发生。
Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis.在他们的研究中,Kittler博士,Bachoo博士和研究小组发现药物米曲兰霉素抑制这些转录因子。
In their study, Dr. Kittler, Dr. Bachoo,and team found the drug mithramycin to inhibit these transcription factors.她的课题组开发了许多被广泛使用及引用的转录因子基序查找算法,ChIP-chip/seq,MNase/DNase-seq和CRISPR筛选数据分析。
We have developed a number of widely used algorithms for transcription factor motif finding, ChIP-chip/ ChIP-seq/ DNase-seq/ CRISPR screen data analysis.在2017年的一篇细胞论文中,基于计算研究,他们假设,在这些区域,转录因子形成水滴,称为相分离凝聚物。
In a 2017 Cell paper, based on computational studies,they hypothesized that in these regions, transcription factors form droplets called phase-separated condensates.该家族的配体结合各种TGF-β受体,导致调节基因表达的SMAD家族转录因子的募集和活化。
Ligands of this family bind various TGF-beta receptors leading to recruitment andactivation of SMAD family transcription factors that regulate gene expression.测试结果表明,一旦被CRISPR激活,三种神经元主转录因子基因会强有力地激活神经元基因。
The tests showed that, once activated by CRISPR,the three neuronal master transcription factor genes robustly activated neuronal genes.RUNX2属于RUNX家族的转录因子,编码的核蛋白有一个RuntDNA结合结构域。
Runx2 is a member of the runt related transcription factor family and encodes a nuclear protein containing Runt DNA binding domain.