Ví dụ về việc sử dụng Asparagine trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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On the other hand, the scientists also restricted the mice's diets,so that they would have a lower asparagine content.
This mutation replaces the aminoacid aspartic acid with the amino acid asparagine at protein position 50, written as Asp50Asn or D50N.
When scientists reduced asparagine in animals with breast cancer, they found that the number of secondary tumours in other tissues fell dramatically.
The current study investigated whether or not limiting the levels of asparagine in the body could help to slow down tumor growth.
For this purpose, Prof. Hannon and team propose to recruit a group of healthy participants,who would then agree to follow a diet low in asparagine.
Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein.
When the availability of asparagine was reduced, we saw little impact on the primary tumor in the breast, but tumor cells had reduced capacity for metastases in other parts of the body.".
When some carb-rich foods are cookedat high temperatures, the amino acid asparagine reacts with sugars in the foods, forming acrylamide.
Asparagine, an amino acid derived from a varied range of foods- including asparagus, fish and potatoes- could be a key nutrient for a deadly form of breast cancer, a new study suggests.
Most acrylamide in food is formedwhen a natural amino acid called asparagine reacts with certain naturally occurring sugars such as glucose.
On the one hand, they administered the mice L-asparaginase, which is chemotherapy drug currently used in the treatment of acute lymphoblastic leukemia,which is known to thrive on asparagine.
Insulin glargine differs from human insulin in that the amino acid asparagine at position A21 is replaced by glycine and two arginines are added to the C-terminus of the B-chain.
Asparagine, an amino acid derived from a varied range of foods- including asparagus, fish and potatoes- could be a key nutrient for a deadly form of breast cancer, a new study suggests.
The amino acid composition of the fruit is not rich,he is represented mainly by 5 amino acids(asparagine, arginine, glutamine, alanine, tyrosine).
One group of cells was unable to produce normal amounts of asparagine(MOLT4),one group produced asparagine at normal levels(REH), and the last group(the control group) was non-malignant(HUVECs).
L-Aspartic Acid plays an important role in the citric acid cycle, or Krebs cycle, during which other amino acids and biochemicals,such as asparagine, arginine, lysine, methionine, threonine, and isoleucine, are synthesised.
If the findings are confirmed in human cells,limiting the amount of asparagine cancer patients ingest could be a potential strategy to augment existing therapies and to prevent the spread of breast cancer.
Other suggested techniques for acrylamide mitigation include the use of minor ingredients(e.g., amino acids, calcium, and citric acid) that interfere with acrylamide formation,and the use of asparaginase to reduce asparagine levels prior to cooking.
Typically, a carbohydrate tree can solely be added to an asparagine residue if the latter is flanked on the C side by X-serine or X-threonine, where X is any amino acid with the exception of proline.[6].
A sequon is a sequence of consecutive amino acids in a protein that can serve as the attachment site to a polysaccharide, frequently an N-linked-Glycan.[1] The polysaccharide is linked to theprotein via the nitrogen atom in the side chain of asparagine(Asn).
Should this experiment succeed in reducing asparagine levels in the participants' bodies, then the researchers would go ahead and recruit participants with a cancer diagnosis for the next phase of their clinical trials.
Precursors of these contaminants can occur naturally in the food matrix, such as in the case of acrylamide beingformed during the Maillard reaction between the amino acid asparagine and a reducing sugar(especially in potato- and cereal-based, heat-treated products).
Since the asparagine side-chain can form hydrogen bond interactions with the peptide backbone, asparagine residues are often found near the beginning of alpha-helices as asx turns and asx motifs, and in similar turn motifs, or as amide rings, in beta sheets.
These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage,position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation.
In mouse studies,“we could reduce metastasis either by changing the ability of tumor cells to make asparagine, by treating mice with a drug that reduces the availability of asparagine in the body, or by eliminating asparagine from the diet,” said Greg Hannon of the Cancer Research UK Cambridge Institute.
These substitutions create a much more stable peptide with a substitution in position 2 to prevent the splitting of DPP-IV,in position 8 to reduce the replacement of asparagine or amide hydrolysis in the aspartic amino acid, in 15 to improve the bioactivity, in 27 To prevent the oxidation of methionine.
Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA(cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296- 299 in the protease domain.