Ví dụ về việc sử dụng Estriol trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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Hormone estriol(30 µg per tablet).
This component is bio-identical to the human hormone estriol.
They are called estrone, estriol, and estradiol.
Estriol glucuronide, the 16α-glucuronide conjugate of estriol.
ESTRADIOL, ESTRONE, and ESTRIOL are the three basic estrogens.
Estrone is one of several natural estrogens, which also include estriol and estradiol.
Both oestrogen and estriol have been linked with breast cancer.
Estriol succinate is or has been marketed in Europe, Hong Kong, and Mexico.[1][2].
Deactivation includes conversion to less-active estrogens, such as estrone and estriol.
Estriol may sometimes be ordered serially to help monitor a high risk pregnancy.
The main components of conjugated estriol are estriol glucuronides and to a lesser extent estriol sulfates.
The triple test looks for high and low levels of alpha-fetoprotein,human chorionic gonadotropin(hCG), and estriol.
Estriol can be measured in maternal blood or urine and can be used as a marker of fetal health and well-being.
During pregnancy,a woman's doctor will occasionally check her levels of estriol to see if the pregnancy is progressing normally.
Estriol is also available in some countries as estriol succinate( brand name Synapause), a dosage- equivalent ester prodrug of estriol.
Unlike the case of the ER, GPER appears to be selective for estradiol, and shows very low affinities for other endogenous estrogens,such as estrone and estriol.
It is notable that unlike estriol, estrone can be metabolized into estradiol, and most of its potency in vivo is in fact actually due to conversion into estradiol.
Estrogen conjugates have been used as pharmaceutical estrogens, as in estrone sulfate as estropipate(piperazine estrone sulfate) and in conjugated estrogens(Premarin)and conjugated estriol(Progynon, Emmenin).
Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDAor Health Canada.
Estrogens include estradiol,the most abundant form in adult females, estriol, the primary estrogen during pregnancy and estrone, which is produced during menopause.
Estriol is poorly bound to sex hormone- binding globulin( SHBG), with much lower binding affinity for this protein, relative to estradiol, and hence a greater fraction available for biological activity.
Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites,estrone and estriol, at the receptor level.
From estrogen, combining estradiol, estriol and estrone, the most active and significant length is the first, it is in it has the ability to convert excess testosterone in peripheral tissues(especially in the fat layer and liver).
Estriol succinate was under development for the treatment of multiple sclerosis in the United States and worldwide, and reached phase II clinical trials for this indication, but development was discontinued due to insufficient effectiveness.[18] It had the tentative brand name Trimesta.[18].
According to another in vitro study however, the RBA of estriol for the ERα and ERβ were 14% and 21% of those of estradiol, respectively, suggesting that unlike estradiol and estrone, estriol may have preferential affinity for ERβ.
Estriol succinate is the generic name of the drug and its INN and BAN.[ 7][ 10][ 17][ 11][ 16] Other synonyms include oestriol succinate, estriol disuccinate, and estriol hemisuccinate.[ 7][ 10][ 17][ 11] When provided as the sodium salt, estriol succinate is known as estriol sodium succinate(BAN) or as oestriol sodium succinate.
According to one in vitro study, the relative binding affinity(RBA) of estriol for the human ERα and ERβ was 11.3% and 17.6% of that estradiol, respectively, and the relative transactivational capacity of estrone at the ERα and ERβ was 10.6% and 16.6% of that of estradiol, respectively.
Unlike estradiol and estrone, estriol is not synthesized in or secreted from the ovaries, and is instead derived mainly if not exclusively from 16α- hydroxylation of estradiol and estrone by cytochrome P450 enzymes( e.g., CYP3A4) mainly in the liver.
However, during pregnancy, estriol is synthesized in very high quantities by the placenta and is the most produced estrogen in the body by far, although circulating levels of estriol are similar to those of other estrogens due to a relatively high rate of metabolism and excretion.
However, during pregnancy, estriol is synthesized in very high quantities by the placenta and is the most produced estrogen in the body by far, although circulating levels of estriol are similar to those of other estrogens due to a relatively high rate of metabolism and excretion.