Ví dụ về việc sử dụng Febuxostat trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid.
It's used in people for whom allopurinol or febuxostat didn't reduce uric levels enough.
Febuxostat is processed mainly by the liver, so it's safe for people with kidney disease.
These types of medication tend to only be used ifpeople are unable to take allopurinol or febuxostat.
Febuxostat is marketed as Adenuric in Europe, Australia, New Zealand and Pakistan.
The level of uric acid in your blood usually begins todrop within days of the first dose of allopurinol or febuxostat.
Febuxostat may be an option if develop side effects from allopurinol or have kidney disease.
Medications to lower uric acid levels(such as allopurinol, febuxostat, or probenecid) are usually taken indefinitely.
Febuxostat is a newer drug that reduces the amount of urate made in the body in the same way that allopurinol does.
The preliminary results show that overall, febuxostat did not increase the risk of these combined events compared to allopurinol.
Febuxostat is in the US pregnancy category C; there are no adequate and well-controlled studies in pregnant women.[1].
Results In total, 6190 patients underwent randomization,received febuxostat or allopurinol, and were followed for a median of 32 months(maximum, 85 months).
Febuxostat inhibits both oxidized as well as reduced form of xanthine oxidase because of which febuxostat cannot be easily displaced from the molybdenum pterin site.[2].
In those cases, combining diuretics with medications that slow the body's production of uric acid,such as allopurinol(Lopurin) or febuxostat(Uloric), can help.
If you're unable to take allopurinol, febuxostat or a uricosuric, or if they don't work for you, you will need to see a rheumatologist for advice.
In those cases, combining diuretics with medications that slow the body's production of uric acid,such as allopurinol(Lopurin) or febuxostat(Uloric), can help.
Febuxostat was discovered by scientists at the Japanese pharmaceutical company Teijin in 1998.[14] Teijin partnered the drug with TAP Pharmaceuticals in the US and Ipsen in Europe.[15][16][17].
Uricosuric agents like probenecid promote the excretion of uric acid by the kidneys,while xanthine oxidase inhibitors like allopurinol and febuxostat decrease uric acid production.
Febuxostat is a non-purine-selective inhibitor of xanthine oxidase.[1] It works by non-competitively blocking the molybdenum pterin center which is the active site on xanthine oxidase.
On November 15, 2017, the FDA alerted the public that preliminary results of the CARES trialshowed an increased risk of heart-related death with febuxostat, compared to allopurinol.
In the UK, NICE has found that febuxostat has a higher cost/benefit ratio than allopurinol and on that basis recommended febuxostat as a second-line drug for people who cannot use allopurinol.[1].
When taking one of these prophylactic orpreventive medications during the first six months of treatment with allopurinol, febuxostat or probenecid, the risk of having a gout attack during this time decreases.
The febuxostat drug labels already carry a Warning and Precaution about cardiovascular events because the clinical trials conducted before approval showed a higher rate of heart-related problems in patients treated with febuxostat compared to allopurinol.
Lesinurad(brand name Zurampic) is a urate transporter inhibitor for treating high blood uric acid levels associated with gout.[1]It is only recommended together with either allopurinol or febuxostat when these medications are not sufficient.[2].
Febuxostat was approved for medical use in the European Union in 2008 and in the United States in 2009.[5][2] No generic version is available as of 2019, though one has been approved.[3][6] In the United Kingdom a month of treatment costs the NHS about 24 pounds.[4] In the United States the wholesale cost of a month's worth of medication is about US$320.
Febuxostat, sold under the brand names Uloric among others, is a medication used long-term to treat gout due to high uric acid levels.[1] It is generally only recommended in those who cannot take allopurinol.[2][3] When initially started, medications such as NSAIDs are often recommended to prevent gout flares.[2][4] It is taken by mouth.[2].
Febuxostat is used to treat chronic gout and hyperuricemia.[8] Febuxostat is typically only recommended in those who cannot tolerate allopurinol.[9] National Institute for Health and Clinical Excellence concluded that febuxostat is more effective than standard doses of allopurinol, but not more effective than higher doses of allopurinol.