Ví dụ về việc sử dụng Hayflick trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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Hayflick interpreted his discovery to be aging at the cellular level.
This is known as the Hayflick limit, and is now a pillar of biology.
Hayflick was the first to report that only cancer cells are immortal.
There's a limit to the number of times a cell can reproduce,called the Hayflick limit.
Hayflick was the first to report that only cancer cells are immortal.
Unlike Carrel's experiment, Hayflick's have been successfully repeated by other scientists.
Hayflick describes three phases in the life of normal cultured cells.
Phase two is defined as theperiod when cells are proliferating; Hayflick called this the time of"luxuriant growth".
Back in July 1973, Hayflick received a call at home from a senior medical officer at NASA.
In scientific cell testing,cycloastragenol has been shown to allow cells to divide past their Hayflick limit.
Hayflick first became suspicious of Carrel's claims while working in a lab at the Wistar Institute.
Their length decreases continuously due to a process called the Hayflick limit- it is the number of divisions of a cell that is approximately equal to 50.
The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division.
Australian Nobel laureateSir Macfarlane Burnet coined the name"Hayflick limit" in his book Intrinsic Mutagenesis: A Genetic Approach to Ageing, published in 1974.[1].
The Hayflick limit has been found to correlate with the length of the telomeric region at the end of chromosomes.
It has been long known that cultured human cells seem able toreplicate no more than 40 to 60 times(called the Hayflick limit) before they stop and become senescent.
Hayflick noticed that one of his cultures of embryonic human fibroblasts had developed an unusual appearance and that cell division had slowed.
With telomerase activation some types of cells andtheir offspring become immortal(bypass the Hayflick limit), thus avoiding cell death as long as the conditions for their duplication are met.
Hayflick demonstrated that a normal human fetal cell population will divide between 40 and 60 times in cell culture before entering a senescence phase.
This shortens the telomere and,after 50-70 such divisions(a number known as the Hayflick limit, after its discoverer), a chromosome can grow no shorter and the cell it is in can divide no more.
Leonard Hayflick suggests that the daily feeding of nutrient was continually introducing new living cells to the alleged immortal culture.[9] J. A.
If you took every cell in your body, at the time you were born, and accounted for all the cells they would produce and so on, multiplied that number by the average time it takes for those cells to die,you get what is known as the ultimate Hayflick limit.
The concept of the Hayflick limit was advanced by American anatomist Leonard Hayflick in 1961,[1] at the Wistar Institute in Philadelphia, Pennsylvania, United States.
If you took every cell in your body, at the time you were born, and accounted for all the cells they would produce and multiplied that number by the average time it takes for those cells to die,you get what is known as the ultimate Hayflick limit or the maximum number of years you can theoretically live.
In fact, in the 1960s, Leonard Hayflick and Paul Moorhead made the important discovery that differentiated cells can undergo only a limited number of divisions in culture before undergoing senescence and dying.
Hayflick next set out to prove that the cessation of normal cell replicative capacity that he observed was not the result of viral contamination, poor culture conditions or some unknown artifact.
The experiment proceeded as follows: Hayflick mixed equal numbers of normal human male fibroblasts that had divided many times(cells at the 40th population doubling) with female fibroblasts that had divided fewer times(cells at the 15th population doubling).
Once Hayflick explained that the abortion from which the cells were derived had occurred legally in Sweden, the physician said that he would defuse the situation- but concerns among anti-abortionists about WI-38 have lasted to this day.”.
Hayflick argues that there are at least four stakeholders with title to WI-38 or any human cell culture: the tissue donors, the scientists whose work gave it value, the scientists' institution and the body that funded the work.
In vitro, when cells approach the Hayflick limit, the time to senescence can be extended by inactivating the tumor suppressor proteins- p53 and Retinoblastoma protein(pRb).[citation needed] Cells that have been so-altered eventually undergo an event termed a"crisis" when the majority of the cells in the culture die.