Ví dụ về việc sử dụng Ion channel trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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Most genes involved affect ion channels, either directly or indirectly.
This action enhances the effect of the neurotransmitter GABA on the GABAA receptorcomplex by increasing the opening frequency of the chloride ion channel.
When RTX binds to TRPV1,it props open the nerve cell's ion channel, letting a whole lot of calcium in.
In neurons, the types of ion channels in the membrane usually vary across different parts of the cell, giving the dendrites, axon, and cell body different electrical properties.
And a division of P2 into P2X andP2Y with seven subtypes of P2X ion channel receptors and eight subtypes of P2Y G-protein-coupled receptors.
RTX causes an ion channel in the plasma membrane of sensory neurons- the transient receptor potential vanilloid 1- to become permeable to cations, most particularly the calcium cation;
As the membrane potential is increased, sodium ion channels open, allowing the entry of sodium ions into the cell.
When an action potential arrives at the end of the pre-synaptic axon(top),it causes the release of neurotransmitter molecules that open ion channels in the post-synaptic neuron(bottom).
In reality, there are many types of ion channels,[33] and they do not always open and close independently.[lower-alpha 10].
Hodgkin and Huxley approached the problem by developing aset of differential equations for the parameters that govern the ion channel states, known as the Hodgkin-Huxley equations.
If they can devise a way to block the ion channel, it may stop those cancerous instructions from getting through.
And the hiPSC-CMs was utilized for their similarities with human primary CMs in terms of the expressions of cardiac-specific genes,structural proteins, ion channels, and more importantly, the spontaneous contraction.
For a long time,it was thought CLCA1 was a chloride ion channel because members of the CLCA protein family appeared to be moving chloride ions in and out of cells.
Ion channel receptors on neurons open or close to allow signals to pass through, and these channels can be activated by chemicals, mechanical processes or temperature, but what exactly about temperature that makes temperature-activated channels activate is unclear.
Thus, in some situations,a rise in the membrane potential can cause ion channels to open, thereby causing a further rise in the membrane potential.
Neurotoxins aimed at the ion channels of insects have been effective insecticides; one example is the synthetic permethrin, which prolongs the activation of the sodium channels involved in action potentials.
The OHSU scientists are interested inexploring another area of research focused on a type of ion channel in the membrane of neurons that is activated by serotonin.
In biological cells, electrochemically active transmembrane ion channel and transporter proteins, such as the sodium-potassium pump, make electricity generation possible by maintaining a voltage imbalance from an electrical potential difference between the intracellular and extracellular space.
This modulation enhances the actions of GABA,causing an increase in opening frequency of the chloride ion channel which results in an increased influx of chloride ions into the GABAA receptors.
This mutation doesn't alter the properties of the sodium ion channel, but does confer resistance to batrachotoxin, meaning that the frogs are free to accumulate it without it killing them.
Deisseroth's lab, including postdoctoral fellow collaborator Edward Boyden, will develop a new tool,based on a genetically encoded light sensitive ion channel from algae, to stimulate electrical activity in specific sets of neurons with light.
Genetic studies suggest that the virus M2 protein, an ion channel specified by virion M2 gene, plays an important role in the susceptibility of influenza A virus to inhibition by rimantadine.
This release of internal Ca2+ is augmented by various Ca2+ entrychannels that belong to the transient receptor potential(TRP) ion channel family, such as canonical TRP 1(TRPC1), vanilloid TRP 2(TRPV2) and melastatin-related TRP 2(TRPM2).
Second, as a member of the lanthanides, it is used in various Ion Channel electrophysiology experiments, where it is used to block sodium leak channels, as well as to stretch activated ion channels. .
Brugada syndrome is agenetic disease that result in mutations in the sodium ion channel(gene SCN5A) of the myocytes in the heart.[6] Brugada syndrome can result in ventricular fibrillation and potentially death.
Whereas cannabidiol directly activates the 5-HT1A serotonin receptor andseveral TRPV ion channels, some studies indicate that Hemp functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55.
While glass micropipetteelectrodes measure the sum of the currents passing through many ion channels, studying the electrical properties of a single ion channel became possible in the 1970s with the development of the patch clamp by Erwin Neher and Bert Sakmann.
Ivacaftor, a CFTR potentiator, improves the transport of chloride through the ion channel by binding to the channels directly to induce a non-conventional mode of gating which in turn increases the probability that the channel is open.[6][7][8].
Ganaxolone binds to allosteric sites of the GABAA receptor to modulate andopen the chloride ion channel, resulting in a hyperpolarization of the neuron.[1] This causes an inhibitory effect on neurotransmission, reducing the chance of a successful action potential(depolarization) from occurring.[1][2][3].