Ví dụ về việc sử dụng Megestrol trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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How should I keep megestrol stored?
How is megestrol acetate powder best taken?
The most common side effect of megestrol acetate is weight gain.
Pregnancy: Megestrol acetate is not recommended for use during the first 4 months of pregnancy.
It is probably even weaker than megestrol acetate(Timpone 1997).
Mọi người cũng dịch
Megace(megestrol acetate) possesses pharmacological properties similar to those of natural progesterone.
What special precautions Before taking megestrol acetate powder?
Do not use megestrol if you are pregnant.
Posted on 07/01/2018 by Dr. Patrick Young wrote in Megestrol acetate. It has 0 Comment.
You should know that megestrol may interfere with the normal menstrual cycle(period) in women.
Because of the potential for adverse effects on the newborn,nursing should be discontinued if Megestrol acetate powder is required.
Types of products: megestrol and medroxyprogesterone.
Clinically apparent adrenal insufficiency has beenrarely reported in patients shortly after discontinuing megestrol acetate.
Active ingredient: megestrol acetate- 160 mg(in 1 tablet);
Hence, it is described as nonsteroidal in order to distinguish it from oldersteroidal antiandrogens such as cyproterone acetate and megestrol acetate.
If your doctor changes your brand, strength, or type of megestrol acetate powder, your dosage needs may change.
Before you take megestrol acetate powder, tell your doctor if you have diabetes or a history of stroke or blood clot.
Based on its chemical structure, namely the lack of a C3 ketone,it is probable that acetomepregenol is a prodrug of megestrol acetate(the 3-keto analogue).[11][12].
Megestrol acetate, a synthetic gestagenic hormone, shows some benefit as an appetite stimulant in wasting syndrome(Von Roenn 1994, Mulligan 2006).
Because elderly patients are more likely to have decreased renal function,care should be taken during treatment with megestrol acetate, and it may be useful to monitor renal function.
In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.
MLGA is the acetate ester of melengestrol, which in contrast, has never been marketed.[1] Analogues of MLGA include other 17α-hydroxyprogesterone derivatives such as chlormadinone acetate, chlormethenmadinone acetate, cyproterone acetate, delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, methenmadinone acetate, and osaterone acetate.[1] The only structural difference between MLGA and megestrol acetate is the presence of the C16 methylene group in the former.[1].
Megestrol acetate powder is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.
As an example, one study in men with benign prostatichyperplasia who were treated with 120-160 mg of megestrol acetate per day for 3 to 11 days found average decreases in AR quantity of 73% and 86% in the cytoplasm and nucleus of prostatic cells.
Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers.
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.
Pharmacologic doses of megestrol acetate not only decrease the number of hormone-dependent human breast cancer cells but also are capable of modifying and abolishing the stimulatory effects of estrogen on these cells.
Tell your doctor and pharmacist if you are allergic to megestrol acetate powder, any other medications, or any of the inactive ingredients in megestrol acetate powder, suspension, or concentrated suspension.
Taking advantage of this side effect, Megestrol acetate has been studied and used to treat severe appetite loss(anorexia), muscle wasting(cachexia) and weight loss associated with cancer and AIDS.
It is the antiandrogenic and antiestrogenic effects of megestrol acetate mediated by suppression of the HPG axis that are mainly responsible for its beneficial effects against androgen and estrogen-sensitive cancers, respectively.