Ví dụ về việc sử dụng Other statins trong Tiếng anh và bản dịch của chúng sang Tiếng việt
{-}
-
Colloquial
-
Ecclesiastic
-
Computer
Adverse effects are comparable to other statins.
As with other statins, atorvastatin is a competitive inhibitor of HMG-CoA reductase.
The evidence for the use of pravastatin is generally weaker than for other statins.
The inhibitory activity of cerivastatin was compared to that of other statins, specifically lovastatin, simvastatin and pravastatin.
This put the risk of this(rare) complication at 5-10 times that of the other statins.
Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of HDL-cholesterol.
We haven't found any convincingevidence that Crestor poses any more of a risk than the other statins," she said.
Like other statins, it is an inhibitor of HMG-CoA reductase, the enzyme that catalyses the first step of cholesterol synthesis.
Also, he said, those who were put on Crestor when it came outwere likely those who had had problems with other statins.
Other statins- it is necessary to monitor the patient's condition in time to detect the signs and symptoms of myopathy.
Meta-analysis showed that rosuvastatin is able to modestly increaselevels of HDL cholesterol as well, as with other statins.
Other statins have shorter half-lives and should be administered in the evening, when synthesis of endogenous cholesterol occurs.
Meta-analysis showed that rosuvastatin is able to modestly increase levels of high-density lipoprotein(HDL)cholesterol as well, as with other statins.
Like the other statins, pitavastatin is indicated for hypercholesterolaemia(elevated cholesterol) and for the prevention of cardiovascular disease.
Therefore, a drug such as"Tsevivastatin"(Baycol) was generally discontinuedbecause it caused the abovedisease 100 times more often than other statins.
Given the evidence of more serious risks andless clinical benefit than other statins how has the drug fared so well for so long?
Lipitor and various other statins are certainly not recommended if you have active liver disease or build a marked elevation of liver enzymes after starting your medication.
There is also growing evidence that the drug carries a higherrisk of serious adverse effects compared with other statins, such as an increased risk of developing diabetes.
When co-administered with simvastatin, or other statins that are CYP3A substrates, dosage adjustment of such statins may need to be considered.
Several cytochrome P450 enzymes(mainly CYP2C9, but also CYP3A4 and CYP2C8)[7] are involved in the metabolism of fluvastatin,which makes is less liable to interactions than most other statins.
As opposed to other statins, there is evidence that pitavastatin improves insulin resistance in humans, with insulin resistance assessed by the homeostatic model assessment(HOMA-IR) method.[10].
Contrary to lovastatin, simvastatin and atorvastatin, fluvastatin has no relevant interactions with drugs that inhibit the liver enzyme CYP3A4,and a generally lower potential for interactions than most other statins.
The company said:“Crestor is an effective treatment for lowering LDL-cholesterol and raising HDL-cholesterol,when compared to other statins, and it has been shown to slow the progression of atherosclerosis.”.
The Lancet's editorial position is that the data for Crestor’s superiority relies too much on extrapolation from the lipid profile data and too little on hard clinical endpoints,which are available for other statins.
Rosuvastatin has structural similarities with most other synthetic statins, e.g., atorvastatin,cerivastatin and pitavastatin, but unlike other statins, rosuvastatin contains sulfur(in sulfonyl functional group).
The Lancet's editorial position is that the data for Crestor's superiority rely too much on extrapolation from the lipid profile data(surrogate end-points) and too little on hard clinical end-points,which are available for other statins that had been on the market longer.
Of Public Citizen both denying the petition and providing an extensive detailed analysis of findings thatdemonstrated no basis for concerns about rosuvastatin compared with the other statins approved for marketing in the United States.[41].
Bayer A.G. added a contraindication for the concomitant use of cerivastatin and gemfibrozil to the package 18 months after the drug interaction was found.[3] The frequency of deadly cases of rhabdomyolysis with cerivastatinwas 16 to 80 times higher than with other statins.[4] Another 385 nonfatal cases of rhabdomyolysis were reported.
For patient who must use atorvastatin at doses higher than 20 mg daily,physician should choose other statin(e.g. pravastatin).