Ví dụ về việc sử dụng Tregs trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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It decreases memory B cells, effector Th1 and Th17 cells,and increases Tregs(R).
Now the stem cells rely on the Tregs completely to know when it's time to start regenerating.”.
Studies have also suggested that cinnamon may protect regulatory T cells,known as Tregs.
In this case, the researchers separated Tregs from the red blood cells and expanded them ex vivo.
In mouse studies, cinnamon treatment has prevented theloss of certain proteins that are specific to Tregs.
Tregs also"control the immune response to self and foreign particles(antigens) and help prevent autoimmune disease.".
In mouse studies, cinnamon treatment has prevented theloss of certain proteins that are specific to Tregs.
We believed that improving the number and function of Tregs in these patients would affect how their disease progressed,” Dr. Appel says.
This has been thought to be an entirely stem cell-dependent process,but it turns out Tregs are essential.
The researchers noticed that in the case of the patients whose Tregs weren't functioning properly, once the cells were outside the body, they returned to normal.
What surprised us," he goes on,"was that the progression of their ALS dramaticallyslowed while they received infusions of properly functioning Tregs.".
He is also working with theUniversity of Florida to develop a trial to test Tregs derived from umbilical cord blood.
Those white blood cells- called Tregs and Th-17- are then able to fight and protect us from fungal infections and harmful pathogens and keep inflammation at bay.
In their study,Sumida and colleagues analysed regulatory T cells(Tregs) taken from people with MS.
Dr Rosenblum said:"It's as if the skin stem cells and Tregs have co-evolved, so that the Tregs not only guard the stem cells against inflammation but also take part in their regenerative work.
Work in mice has found that T cells that recognise and bind with one of these peptides(and which would normally attack them)are reprogrammed into Tregs;
We found," notes Dr. Appel,"that many of our ALS patients not only had low levels of Tregs, but also that their Tregs were not functioning properly.".
It's as if the skin stem cells and Tregs have co-evolved, so that the Tregs not only guard the stem cells against inflammation but also take part in their regenerative work," Rosenblum said.
One explanation for a possible mechanism is this observation that TNF has apositive effect on regulatory T cells(Tregs), due to its binding to the Tumor necrosis factor receptor 2(TNFR2).
In addition, the number of CD4+CD25++FOXP3+ Tregs in peripheral blood was assessed by flow cytometry, and the levels of TGF-β and IL-10 were determined in serum samples by enzyme-linked immunosorbent assay before and after….
In a mouse model, Michael Rosenblum, Ph.D., an assistant professor of dermatology at UCSF,and colleagues found that Tregs trigger stem cells in the skin, which promote healthy hair.
The researchers used RNA sequencing to analyze Tregs further, and they found that a protein called beta-catenin plays a key role in both keeping Tregs functional and regulating the two pro- and anti-inflammatory cytokines mentioned above.
In most people, this misfiring of the immune system is prevented by anotherkind of T-cells called Regulatory T-cells, or Tregs, that suppress other T-cell responses when necessary.
When Roquin is lacking, the ability of Tregs to control the course of immune reactions is therefore perturbed in two ways.: Treg-mediated inhibition of immune responses outside the germinal center is reduced, however, Tfr-mediated inhibition of antibody production within the germinal centers is enhanced.
Asked about the clinical implications of his findings, Sumida said,“Not only upregulation of the pro-inflammatory cytokine IFN-gamma but also downregulation of the anti-inflammatorycytokine IL-10 might mark dysfunctional(Tregs) in MS patients.”.
University of California-San Francisco(UCSF)researchers reported that defects in a type of immune cell called Tregs- which are usually associated with controlling inflammation- might be responsible for a different kind of hair loss: alopecia areata.