serious adverse reactions serious adverse reaction serious affair serious ailments serious all the time serious allegations serious allegation serious allergic reactions serious allergic reaction serious allergies serious alternative serious amount serious analysis serious anomaly serious answer serious anxiety serious approach serious argument serious arrhythmia serious artist serious art serious as a heart attack serious assault serious assessment serious athletes serious attacks serious attack serious attempts serious attempt serious attention serious attitude serious barrier serious basis serious battle serious birth defects serious bleeding serious blood infection serious blood serious blow serious blunder serious book serious boost serious boyfriend serious boy serious brain damage serious brain injury serious brain serious breaches serious breach serious breakdown serious breathing problems serious bug serious burden serious burns serious businessman serious business serious buyers serious buyer serious candidate serious can serious cardiovascular events serious cardiovascular serious cases of corruption serious cases serious case serious cash serious casualties serious cause serious challenges serious challenge serious chance serious changes serious character serious charges serious charge serious chronic serious circumstances serious clashes serious collector serious collision serious commitment serious communication serious company serious competition serious competitor serious complaints serious complication that can serious complications serious complication serious computer serious concerns regarding serious concerns serious concern serious concussion serious condition called serious conditions serious condition serious conflict of interest serious conflicts serious conflict serious confrontation serious consequences for women serious consequences serious consideration serious constraint serious contamination serious contender serious contradictions serious contraindications serious contribution serious conversation serious cooperation serious corrosion serious crash serious crimes serious crime serious criminal activity serious criminal offences serious criminal offence serious criminal offense serious criminal serious crises serious crisis of confidence to the serious crisis serious crisis serious criticism serious cross-border health threats serious cross-border serious cuts serious damage to health serious damage to the environment serious damages serious damage to serious damage serious danger serious data serious dating serious debate serious debt serious decision serious decline serious decrease serious defeat serious defects serious deficiencies serious deficit serious degradation serious delays serious democratic deficit serious dent serious departure serious depression serious design serious destruction serious deterioration serious developments serious deviation serious diagnosis serious dialogue serious differences of opinion serious differences serious difficulties serious difficulty serious dilemma serious diplomatic serious disability serious disadvantage serious disagreements serious disagreement serious disasters serious discomfort serious discrimination serious discussions serious discussion serious diseases to serious diseases serious disease serious disorder serious disparities serious disputes serious disregard serious disruptions serious disruption serious distortions serious disturbance in the economy serious disturbances serious disturbance serious divisions serious doubts serious doubt serious drama serious drawback serious drinking problem serious drop serious drought serious drug problem serious drug serious earthquake serious economic consequences serious economic crisis