severe intoxication severe irritation severe issues severe itching of the skin severe itching severe joint pain severe judgment severe keratitis severe kidney disease severe kidney problems severe kidney severe lacerations severe lack severe laws severe lesions severe limitations severe limits severe liver damage severe liver disease severe liver severe local severe losses severe loss severe lung severe malaria severe malnutrition severe material severe measures severe medical condition severe medical severe mental disorders severe mental illness severe migraines severe migraine severe muscle pain severe muscle severe myelosuppression severe myopia severe natural disasters severe nausea severe negative effects severe negative impact severe neurological severe neutropenia severe nosebleeds severe obesity severe obstacles severe osteoarthritis severe osteoporosis severe overdose severe pain in the abdomen to severe pain severe pain severe pathology severe penalties severe peripheral neuropathy severe persecution severe persistent severe phenotype severe physical severe pneumonia severe poisoning severe pollution severe poverty severe power severe pressure severe problems severe problem severe pruning severe psoriasis severe psychiatric severe psychological trauma severe psychological severe ptsd severe pulmonary severe punishment severe rash severe reactions severe reaction severe recession severe redness severe reduction severe renal disease severe renal dysfunction severe renal failure severe renal impairment severe renal insufficiency severe renal severe repercussions severe repression severe reprimand severe respiratory depression severe respiratory disease severe restrictions severe rheumatoid arthritis severe rises severe risk severe sanctions severe seizures severe sentences severe sepsis severe setback severe shock severe shortage severe shortcomings severe shortness of breath severe side effects severe side-effects severe signs severe situation severe skin rash severe skin reactions severe skin reaction severe skin severe social problems severe social severe stage severe stomach pain severe stomach severe storms severe storm severe strain severe stress severe stroke severe suffering severe sunburn severe sweating severe swelling severe symptoms severe tensions severe test severe threat severe thrombocytopenia severe thunderstorms severe thunderstorm severe tiredness severe torment severe torture severe toxicity severe trauma severe treatment severe trials severe trouble severe turbulence severe type severe ulcerative colitis severe uncontrolled severe unemployment severe vibration severe view severe violation severe violence severe virus severe visual impairment severe vomiting severe vulnerabilities severe warning severe weakness severe wear severe weather conditions severe weather severe weight loss severe wind severe winters severe winter severe workouts severe wounds severed arm severed diplomatic relations severed ears severed finger severed foot severed hand severed heads severed head severed leg severed limbs severed penis severed ties severed tongue severed severely affected by the crisis severely affected severely affect severely beaten severely burned severely compromised severely constrained severely contaminated severely corrupted severely criticised severely criticized severely curtailed severely damaged severely damage severely debilitating severely decreased severely deformed severely degraded severely dehydrated