significant contamination significant content significant contraction significant contracts significant contrast significant contribution to the development significant contributions significant contribution significant contributor significant control significant controversy significant convergence significant cooperation significant coordination significant correction significant correlation significant cost reduction significant cost savings significant cost-savings significant costs significant cost significant covariate significant coverage significant credit significant criticism significant cross-border significant cultural significant customer significant cuts significant damage significant danger significant data significant date significant day significant debate significant debt significant deceleration significant decisions significant decision significant decline in the number significant decline significant decreases to a significant decrease significant decrease significant defeat significant defects significant deficiencies significant deformation significant degradation significant degree significant delays significant delay significant demand significant departure significant deposits significant design significant destruction significant detail significant deterioration significant developments significant development significant deviations significant deviation significant differences between countries significant differences between member states significant differences exist significant differences of opinion to significant differences significant differences significant difference significant difficulties significant digits significant dimension significant direct significant disability significant disadvantage significant discomfort significant discounts significant discount significant discoveries significant discrepancies significant disparities significant displacement significant disruption significant distance significant distinction significant distortions of competition significant distortions significant distress significant distribution significant disturbance significant divergences significant divergence significant diversity significant document significant dose significant doubts significant downturn significant drawbacks significant drawback significant driver significant drop significant earthquake significant economic activity significant economic advantages significant economic benefits significant economic contribution significant economic costs significant economic damage significant economic development significant economic factor significant economic growth significant economic impact significant economic importance significant economic losses significant economic opportunities significant economic value significant economic significant economies of scale significant effect on the pharmacokinetics significant effects on the environment significant effects significant effect significant efficacy significant efficiency significant efforts are needed significant efforts have been made significant efforts to reduce significant efforts significant effort significant elements significant element significant elevations significant emissions significant emphasis significant employment significant energy savings significant energy significant enhancement significant enlargement significant environmental aspects significant environmental benefits significant environmental damage significant environmental effects significant environmental impacts significant environmental impact significant environmental risks significant environmental significant episode significant erosion significant errors significant european significant events significant event significant evidence significant evolution significant example significant exception significant excess significant expansion significant expenditure significant experience significant expertise significant exporter significant exposure significant extension to a significant extent significant extent significant external significant extra costs significant factors significant factor significant fact significant fall significant feature significant figures significant figure significant files significant financial benefits significant financial burden significant financial contribution significant financial impact significant financial implications significant financial investment significant financial losses significant financial resources significant financial risk significant financial savings significant financial support significant financial significant financing significant findings significant find significant fines significant flaws significant flexibility significant flows significant fluctuations significant focus significant force