Eksempler på brug af Dose escalation på Engelsk og deres oversættelser til Dansk
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Dose escalation to 600 mg twice daily was allowed.
Dosiseskalering til 600 mg to gange dagligt var tilladt.Steroids may be discontinued as appropriate,once dose escalation has been achieved.
Steroider kan seponeres efter behov,så snart dosisøgningen er gennemført.Dose escalation should be based upon clinical response and tolerability.
Dosisregulering bør baseres på klinisk respons og tolerabilitet.If therapy is withheld for more than 7 days,MabCampath should be reinstituted with gradual dose escalation.
In most patients, dose escalation to 30 mg can be accomplished in 3-7 days.
Hos de fleste patienter kan dosisøgning op til 30 mg gennemføres på 3- 7 dage.The daily dose was escalated to 800 mg in a total of 103 patients; 6 patients achieved a partial response and21 stabilisation of their disease after dose escalation for an overall clinical benefit of 26.
Opnåede delvist respons og21 patienter opnåede stabilisering Dose escalation, when indicated, should be conservative in such patients.
Optrapning af dosis, når indiceret, bør hos sådanne patienter foretages med forsigtighed.Once a dose has been reduced because of toxicity, dose escalation in the subsequent cycles is not recommended.
Hvis en dosis er blevet reduceret på grund af toksicitet, frarådes det at foretage dosisoptrapning i de efterfølgende cyklusser.Dose escalation may decrease, though not eliminate, the risk of nausea and dizziness.
Dosiseskalering kan sænke, men ikke udelukke, risikoen for kvalme og svimmelhed.Patients should be monitored closely following dose escalation given the potential for an increased incidence of adverse reactions at higher dosages.
Patienterne bør monitoreres tæt under dosiseskaleringen, da der er mulighed for øget forekomst af bivirkninger ved højere doseringer.Dose escalation should continue in a stepwise manner until adequate analgesia is achieved.
Dosisoptrapning skal fortsætte trinvist, indtil der er opnået tilstrækkelig analgesi.Adults aged 18 years and above- recommended dose escalation to the maintenance total daily stabilisation dose in treatment of bipolar disorder.
Voksne i alderen 18 år og derover- anbefalet dosisøgning til den samlede daglige vedligeholdende stabiliseringsdosis ved behandling af bipolar sygdom.Dose escalation or bolus doses of Xigris are not necessary to account for the interruption in the infusion.
Det er ikke nødvendigt at øge dosis eller Specific patient groups Elderly BYETTA should be used with caution and dose escalation from 5 µg to 10 µg should proceed conservatively in patients> 70 years.
Specifikke patientgrupper Ældre patienter BYETTA bør bruges med forsigtighed, og dosisøgning fra 5 µg til 10 µg bør foregå forsigtigt hos patienter> 70 år.In this study, dose escalations were allowed from 400 mg daily to 600 mg daily, then from 600 mg daily to 800 mg daily.
I dette studie var dosisoptrapning tilladt fra 400 mg daglig til 600 mg daglig og derefter fra 600 mg daglig til 800 mg daglig.If these events are moderate to severe, then dosing should continue at the same level prior to each dose escalation, with appropriate premedication, until each dose is well tolerated.
Hvis disse hændelser er moderate til alvorlige, bør doseringenfortsætte på det samme niveau forud for hver dosisøgning, og med passende præmedicinering, indtil hver dosis tåles godt.When indicated, dose escalation should be performed with caution in these patients.
Hvis det er indiceret, bør dosisoptrapning foretages med forsigtighed hos disse patienter.Although comparative data are lacking, limited data in patients who initially responded to 5 mg/ kg butwho lost response indicate that some patients may regain response with dose escalation see section 5.1.
Selvom sammenlignende resultater mangler, indikerer begrænsede data hos patienter,der initialt responderede på 5 mg/ kg, men som mistede respons, at nogle patienter kan genvinde respons med dosisoptrapning se pkt.Patients should be instructed that dose escalation is not to occur if any rash occurs during the two-week lead-in dosing period, until the rash resolves.
Patienterne skal instrueres i at dosisøgning ikke må foretages, hvis nogen form for udslæt opstår i løbet af den to- ugers optrapningsperiode, før udslættet er forsvundet.The daily dose was escalated to 800 mg in a total of 103 patients; 6 patients achieved a partial response and21 stabilisation of their disease after dose escalation for an overall clinical benefit of 26.
Den daglige Acute adverse reactions, which may occur during initial dose escalation and some of which may be due to the release of cytokines, include hypotension, chills/ rigors, fever, shortness of breath and rashes.
Akutte bivirkninger, som kan opstå i løbet af den initiale dosisoptrapning, og hvor nogle In an open-label extension study, for patients who dose escalated from 40 mg every other week to 40 mg weekly due to a PASI response below 50 andwere evaluated at 12 weeks after dose escalation, 59/ 243(24.3%) of patients regained PASI 75 response.
I et åbent forlængelsesforsøg, med patienter, hvis dosis blev trappet op fra 40 mg hver anden uge til 40 mg ugentligt pågrund af PASI- respons under 50, og som blev evalueret 12 uger efter dosis- stigning, genvandt 59/ 243(24, 3%) af patienterne PASI- 75- respons.In a dose escalation study in patients on chronic levodopa therapy treated with 10 mg/ day of rasagiline, there were reports of cardiovascular undesirable effects(including hypertension and postural hypotension) which resolved following treatment discontinuation.
I en undersøgelse med stigende dosis til patienter i vedvarende levodopabehandling The initiation of adjunctive therapy with Diacomit should be undertaken over 3 days using upwards dose escalation to reach the recommended dose of 50 mg/ kg/ day administered in conjunction with clobazam and valproate.
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