Exemplos de uso de Prior use of antibiotics em Inglês e suas traduções para o Português
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Time on MV and prior use of antibiotics were independent risk factors for VAP.
In practice, the main impediment to isolating the pathogen is the prior use of antibiotics.
The prior use of antibiotics, in similar contexts, might not interfere with the yield of respiratory cultures.
Blood culture negativity was more frequent than in other series,probably due to referral bias and prior use of antibiotics.
In this perspective, association of bacterial resistance with prior use of antibiotics for a long period, indicates that their indiscriminate use is dangerous.
It is important to bear in mind that the culture of the exudates may be negative,which is typically attributable to prior use of antibiotics.
The independent variables tested in the models for the VAP acquisition outcome were time on MV, prior use of antibiotics, age, incidence of tracheostomy, indication for MV and diagnostic category.
The secondary outcomes assessed were in-hospital mortality, risk factors for VAP acquisition,microbiological profile and prior use of antibiotics.
This finding is consistent with the Brazilian guidelines for the treatment of HAP and VAP,which state that the prior use of antibiotics in the 15 days preceding the disease is an important risk factor for potentially resistant pathogens.
In the present study, the independent risk factors for the development of VAP identified using multivariate analysis were time on MV and prior use of antibiotics.
Multiple logistic regression analysis demonstrated that time on MV OR 1.07; 95% CI: 1.05-1.10,p< 0.0001 and prior use of antibiotics OR 2.36; 95% CI: 1.12-4.99, p 0.023 were independent risk factors for the development of VAP.
In both methods, the result is positive in a variable percentage of cases, depending on the etiologic agent,the age of the patient, and the prior use of antibiotics.
Age, gender, reason for ICU admission, prior use of antibiotics, and clinical laboratory data, as well as a lung injury score, a radiological score, and the Acute Physiology and Chronic Health Evaluation II score on the day of inclusion.
A statistically significant association was found only with antibiotic resistance, prior use of antibiotics, and presence of wounds.
Based on the analysis of the ROC curve, we can conclude that, of these two variables, although prior use of antibiotics has an OR that demonstrate a closer relationship with VAP acquisition, time on MV has greater reproducibility, with higher sensitivity and higher specificity, and this is revealed by the area under the curve above 0.8, for the cut-off point of 12 days.
The analysis of the performance of these variables using the ROC curve revealed that the area under the curve was 0.82 95% CI:0.76-0.87 and 0.59 95% CI: 0.52-0.65, respectively, for time on MV and for prior use of antibiotics Figure 2.
Part of this uncertainty is due to the major variability of the methods used in these studies different collection methods, prior use of antibiotics, variations in culture methods, besides the difficulties in distinguishing which are the pathogens and which are only colonizing agents.
Risk factors for repeated exacerbations include low pre-treatment FEV1, increased use of bronchodilators or corticosteroids,previous exacerbations more than two in the last two years, prior use of antibiotics, and presence of comorbid conditions.
Result variability from CRS studies are due to the different techniques used as harvesting method,variations in culture methods, prior use of antibiotics and, especially, difficulties in distinguishing which are the colonizing agents and which are truly pathogenic, making it impossible to reach a definitive result today.
In a study with hospital patients in Madagascar, presence of S. aureus in their nostrils was significantly associated with prior use of antimicrobial agents andprior hospitalization, whereas prior use of antibiotics was significantly associated with presence of MRSA.
The management of these patients was performed following the same treatment algorithm Figures 1 and 2. At each hospital studied, the following data were collected from the medical charts: age; gender;use of thoracentesis; use of antibiotics prior to surgery; macroscopic aspect, biochemical analysis, microscopy and culture of pleural fluid; time elapsed from the onset of the clinical symptoms to thoracoscopy; duration of chest tube drainage; length of hospital stay; efficacy of thoracoscopy; and need for a second surgical procedure.
Risk factors associated with sepsis by Acinetobacter are: prior use of broad-spectrum antibiotics, use of urinary catheters, mechanical ventilation and previous surgery.
We found that 34 patients 12.4% had a history of use of antibiotics prior to hospitalization, 160 58.4% initiated treatment in the hospital, and no information regarding antibiotic use was available in the remaining 80 charts.