Exemplos de uso de To increased exposure em Inglês e suas traduções para o Português
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Concomitant administration of CYP3A4 inhibitors will lead to increased exposure of rimonabant.
The presence of bacteria within the ileal cells could lead to increased exposure to toxins or other injury-causing substances and, consequently, to malabsorption, favoring penetration by bacterial and dietary antigens.
In these patients, the prolonged elimination half-life may lead to increased exposure.
Melanoma incidence has increased mainly due to increased exposure to the sun and longer life expectancy.
Intuniv can be administered with or without food butshould not be administered with high fat meals, due to increased exposure see section 5.2.
Herding and hunting dogs are at higher risk due to increased exposure to vectors like sand flies, lice, fleas, and ticks.
Allergies, inflammation, irritation, infections,dryness and flakiness are some skin problems which are growingly affecting more and more number of people due to increased exposure to harsh chemicals and lifestyle stress.
It is speculated that this higher rate of infection may be related to increased exposure to other immunosuppressants, comorbid conditions, use of corticosteroid and disease activity.
Topotecan is partly eliminated via renal excretion andrenal impairment might lead to increased exposure to topotecan.
Intuniv should not be administered with high fat meals due to increased exposure, as it has been shown that high fat meals have a significant effect on the absorption of guanfacine.
Co-administration with EVOTAZ has the potential to produce serious and/or life-threatening bleeding due to increased exposure to warfarin and has not been studied.
Renal and hepatic impairment Due to increased exposure in moderate renal and mild to moderate hepatic impairment, dosing recommendations to titrate according to individual tolerability should be closely followed see section 5.2.
Weight-normalised belimumab dosing leads to decreased exposure for underweight subjects(BMI< 18.5) and to increased exposure for obese subjects BMI> 30.
However, due to increased exposure in these populations dosing recommendations to titrate according to individual tolerability should be closely followed as patients with clinically significant renal or hepatic impairment might experience more dose-dependent adverse reactions.
In a study of sunscreen use among children, Autier et al7(1999)found increased numbers of nevi related to increased exposure to the sun and to use of sunscreen.
However, due to increased exposure in these populations dosing recommendations to titrate according to individual tolerability should be closely followed as patients with clinically significant renal or hepatic impairment might experience more adverse reactions see sections 4.4 and 5.2.
Due to the limited pharmacokinetic data in patients with hepatic impairment,posaconazole should be used with caution in patients with severe hepatic impairment since the prolonged half-life that may occur will lead to increased exposure.
The results previously achieved indicate a correlation between the expansion of urbanization, above all, the state of economic growth andsome municipalities related to agribusiness with the increase in planted area toward a mechanized agriculture and a tendency to increased exposure of certain strata of population at risk of conditions that can cause an increase in some types of cancers, especially cancers of the stomach, liver and pancreas.
It was observed that the traumatic injuries occurred more frequently at night-time and evening and on Sundays and Saturdays, which are associated with alcohol consumption, with higher rates of traffic accidents, drug use, which, in turn,is also related to increased exposure to violence.
Substituting artificial tanning for suntanning in order to obtain or maintain a"healthier","more attractive" complexion is related to an increase in risk,since it leads to increased exposure to UV radiation and to the exposure of individuals with higher risk phototypes.
Studies have shown that the vast majority of motorcyclists had time of professional activity greater than two or five years,making these drivers more vulnerable to accidents when there is longer time of service, due to increased exposure to risk factors inherent in traffic.
The International Olympic Committee's decision in 2009 to add rugby sevens to the Summer Olympics beginning in 2016 has added a boost to rugby sevens and to the World Sevens Series;this boost has led to increased exposure and revenues, leading several of the core teams to field fully professional squads.
Thus, a possible explanation for the association of low estradiol levels and the presence of ACA would be the increased activation of endothelial apoptosis caused by the low endogenous estrogen levels,leading to increased exposure to endothelial and even subendothelial antigens, such as oxidized LDL.
The increasing incidence of skin cancers, including melanoma,has been attributed to increasing exposure of the population to sunlight.
One of these ideas is to increase exposure to your site by having over 750,000 incoming links from websi….
Based on population pharmacokinetic analysis,the presence of an opioid appeared to increase exposure by about 11.
Protease inhibitors: The co-administration of REYATAZ/ritonavir and other protease inhibitors has not been studied butwould be expected to increase exposure to other protease inhibitors.
The co-administration of REYATAZ/ ritonavir and other protease inhibitors has not been studied butwould be expected to increase exposure to other protease inhibitors.
On account of the positive expectations, the decision to increase exposure in shares to 30% of the total investments was made in late 2007.
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