Exemplos de uso de Unchanged in urine em Inglês e suas traduções para o Português
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Is excreted unchanged in urine.
Less than 0.2% of the ospemifene dose was excreted unchanged in urine.
It is extensively excreted unchanged in urine(approximately 60% of the dose) and in vitro metabolism is very slow.
Aprepitant is not excreted unchanged in urine.
Mean half-life(t1/2) andfraction excreted unchanged in urine(Ae) of caffeine in infants are inversely related to gestational/ postmenstrual age.
Less than 1% of the dose is excreted unchanged in urine.
Renal clearance of unchanged drug is a minor pathway of elimination,less than 0.2% of the ospemifene dose is excreted unchanged in urine.
A small amount of caspofungin is excreted unchanged in urine approximately 1.4% of dose.
Safinamide undergoes almost complete metabolic transformation<10% of the administered dose was found unchanged in urine.
Metabolism Sitagliptin is primarily eliminated unchanged in urine, and metabolism is a minor pathway.
Lenalidomide is poorly metabolized as 82% of the dose is excreted unchanged in urine.
Metabolism Sitagliptin is primarily eliminated unchanged in urine, and metabolism is a minor pathway.
Tolcapone is almost completely metabolised prior to excretion, with only a very small amount(0.5% of dose)found unchanged in urine.
Both the drugs have very low plasma protein binding, no metabolism andis excreted unchanged in urine; dose modification is needed in renal impairment.
Fluconazole, a moderate CYP2C9 inhibitor,increased lesinurad AUC(56%) and Cmax(38%), as well as the amount of lesinurad excreted unchanged in urine.
With increasing renal impairment, from mild(CLcr 50 to< 80 ml/min) to moderate(CLcr 30 to< 50 ml/min) to severe renal impairment(CLcr< 30 ml/min), the fraction of regadenoson excreted unchanged in urine and the renal clearance decreased, resulting in increased elimination half- lives and AUC values compared to healthy subjects CLcr ml/min.
The majority of pirfenidoneis excreted as the 5-carboxy-pirfenidone metabolite(> 95% of that recovered), with less than 1% of pirfenidone excreted unchanged in urine.
Approximately 5% is excreted unchanged in urine.
Only 1% to 2% of the caffeine dose taken is eliminated unchanged in urine.
Pemetrexed is primarily eliminated in the urine, with 70% to 90% of the administered dose being recovered unchanged in urine within the first 24 hours following administration.
Umeclidinium bromide plasma elimination half-life following inhaled dosing for 10 days averaged 19 hours,with 3% to 4% active substance excreted unchanged in urine at steady-state.
Elimination Aprepitant is not excreted unchanged in urine.
Umeclidinium plasma elimination half-life following inhaled dosing for 10 days averaged 19 hours in healthy volunteers,with 3% to 4% excreted unchanged in urine at steady-state.
Less than 1% of the dose is excreted unchanged in urine.
Tenofovir is primarily excreted by the kidney by both filtration and an active tubular transport system(human organic anion transporter[hOAT1]) with approximately 70-80% of the dose excreted unchanged in urine following intravenous administration.
Only traces of entacapone are found unchanged in urine.
About two third of the dose are excreted unchanged in urine.
Only traces of entacapone are found unchanged in urine.
Following a 0.24 mg/kg dose in healthy volunteerswith normal renal function, approximately 70% of the dose was excreted unchanged in urine during the first 24 hours following administration.
Tenofovir is primarily excreted by the kidney by both filtration andan active tubular transport system with approximately 70-80% of the dose excreted unchanged in urine following intravenous administration.