Fish kills in USA and Canada have been associated withazinphos-methyl in water at concentrations of 0.30-18.6 ug/L(PMRA, 2003).
鉴于其正辛醇/水分配系数为2.96,谷硫磷可能会发生生物累积(虫害防治管理局,2003年)。
No data are available. Bioconcentration Azinphos-methyl has a potential for bioaccumulation as its octanol-water partition coefficient,Log Kow is 2.96(PMRA, 2003).
In Canada however, PMRA reviewed environmental and health risks from alternatives in use and considered them acceptable(Annex F responses, Canada 2007).
Dose-related inhibition of plasma, erythrocyte and brain cholinesterase activity occurs by all routes andfollowing exposures of various durations(PMRA, 2003).
However, review of this data did not result in significant changes to the occupational risk assessment andrisks still exceeded the level of concern(PMRA, 2007).
Canada Significant challenge for PMRA is a regulatory decision that moves towards the goal of eliminating azinphos-methyl in a manner that is the least disruptive to the need to protect agricultural crops from pests.
为了应对该挑战,虫害防治管理局已考虑了替代品的可得性和不存在替代品或替代品有限的用途的过渡期需求。
To meet its challenge, the PMRA has considered the availability of alternatives and the need for a transition period for those uses for which no or limited alternatives are available.
Alternative pesticide products have been reviewed by the PMRA and have been determined to be efficacious for each registered pesticide use(Annex F responses, Canada 2007).
There was no evidence in the available database to suggest that azinphos-methyl has anadverse effect on the endocrine system in mammals(PMRA, 2003; EU Pesticide Monograph, 1996; NAIS, 2002; JMPR, 1991, 2007).
加拿大卫生部虫害防治管理局.
Pest Management Regulatory Agency, Health Canada.
虫害防治管理局已决定逐步淘汰谷硫磷的所有用途。
The Pest Management Regulatory Agency has determined that all uses for azinphos-methyl are to be phased out.
因此,它不符合持久性标准(虫害防治管理局,2003年)。
Therefore it does not meet the criteria for persistence(PMRA, 2003).
急性参考剂量设定为0.007毫克/千克体重/天(虫害防治管理局,2003年)。
The ARfD was set at 0.007 mg/kg bw/day(PMRA, 2003).
在一起案例中,可能因处理谷硫磷导致原有皮肤干燥加重(虫害防治管理局,2003年)。
In one case, handling of azinphos-methyl possiblyled to exacerbation of existing dry skin(PMRA, 2003).
所有其他组别的潜在日摄入量低于急性参考剂量的48%(虫害防治管理局,2003年)。
All other subpopulations had potentialdaily intakes less than 48% of the ARfD(PMRA, 2003).
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