MyHep所有药物都是sofosbuvir 和velpatasvir的组合。 MyHep All medication is a combination of sofosbuvir and velpatasvir. Sofosbuvir (PSI-7977)是HCVRNA复制抑制剂,EC50为92nM。Sofosbuvir (PSI-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM. 该药物在与sofosbuvir 组合的短短6周内显示出100%的治愈率。 The drug has shown a 100% cure rate in as little as 6 weeks in combination with sofosbuvir . 在基因型2和3HCV感染中,sofosbuvir 可与达卡他韦联合使用。 In genotype 2 and 3 HCV infections, sofosbuvir can be used in combination with daclatasvir. Ledipasvir和sofosbuvir 是2种丙型肝炎病毒(HCV)抗病毒药物的组合。 Ledipasvir& Sofosbuvir is a combination of 2 hepatitis C virus(HCV) antiviral agents.
所有的20名患者服用了6周的sofosbuvir 和ledipasvir没有利巴韦林的药物。 All 20 patients completed six weeks of Sofosbuvir and Ledipasvir without Ribavirin. Ledipasvir和sofosbuvir 是2种丙型肝炎病毒(HCV)抗病毒药物的组合。 Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus(HCV) antiviral agents. NS5B核苷聚合酶抑制剂sofosbuvir 具有最高的耐药屏障[82]。 The NS5B nucleoside polymerase inhibitor sofosbuvir has the highest barrier to resistance[82]. Sofosbuvir (SOF)在发展中国家很容易获得,剂量为400mg/天。Sofosbuvir (SOF), which is easily available in the developing world, is taken as a 400-mg tablet once daily. 不建议HARVONI与其他含sofosbuvir (SOVALDI®)产品使用。 Patients should not take Harvoni with other products that contain sofosbuvir (e.g. Sovaldi). Sofosbuvir 在药物的核苷酸类似物家族中并且通过阻断丙型肝炎NS5B蛋白起作用。Sofosbuvir is in the nucleotide analog family of medication and works by blocking the hepatitis C NS5B protein. 岁的HanyTawfik是私人股权专家,他在2014年是第一位接受sofosbuvir 的埃及人。 Asked Hany Tawfik, 66, a private equity specialist who in 2014 was the first Egyptian to receive sofosbuvir . FDA批准simeprevir联合sofosbuvir 用于治疗基因型1型的HCV感染. Janssen submits sNDA to FDA for simeprevir in combination with sofosbuvir for treatment of HCV genotype 1 infection. Ledipasvir和sofosbuvir 是药物转运蛋白P-gp和BCRP的底物而GS-331007不是。 Sofosbuvir is a substrate of drug transporter P-gp and breast cancer resistance protein(BCRP) while GS-331007 is not. 这些最新报告在2011年底在FDA批准了两种口服HCV药物:simeprevir(Olysio)和sofosbuvir (Sovaldi)。 In late 2013, two new HCV therapies were approved by the FDA, simeprevir(Olysio) and sofosbuvir (Sovaldi)1. Sofosbuvir (Sovaldi)在2013年获得FDA批准,是第一种被认为无干扰素安全有效的药物。Sofosbuvir (Sovaldi) received FDA approval in 2013, and was the first drug deemed safe and effective without interferon. 吉利德的sovaldi的主要成分为sofosbuvir ,harvoni则是sofosbuvir和另一个化合物ledipasvir组合。 Sovaldi is based on the compound sofosbuvir , while Harvoni combines sofosbuvir with the compound ledipasvir. 告诉你的医生或牙医你接受任何医疗或牙科护理,紧急护理或手术之前服用ledipasvir和sofosbuvir 。 Tell your doctor or dentist that you take Ledipasvir& Sofosbuvir before you receive any medical or dental care, emergency care, or surgery. 而为期12周的索华迪(Sofosbuvir )治疗,就是未涵盖在基本保险内的医治丙型肝炎的方案之一,费用为69,600元人民币(约9,700美元)。 A 12-week Sofosbuvir course, one of the treatments not covered by primary insurance, costs 69,600 yuan($ 9700 USD). ASTRAL-3临床试验报道,基因3型患者予sofosbuvir +velpatasvir联合治疗12周后,SVR12为95%[57]。 The ASTRAL-3 trial reported an SVR 12 of 95% in genotype 3 patients treated with sofosbuvir + velpatasvir for 12 weeks[57]. HARVONI是一种两药固定剂量复方产品,在单一片中含90mgledipasvir和400mgsofosbuvir 。 Harvoni is a two-drug fixed-dose combination product that contains 90 mg of ledipasvir and 400 mg of sofosbuvir in a single tablet. 已经证明其他药物,如波普瑞韦,特拉匹韦和sofosbuvir 可以提高这种治愈率,尽管这些药物都会带来额外的副作用。 Other drugs, such as boceprevir, telaprevir and sofosbuvir , have been shown to improve this cure rate, though all carry additional side effects. 最近被FDA批准的全基因型复合制剂之一,商品名为Epclusa,包含sofosbuvir +velpatasvir[55]。 One of the most recent FDA-approved pan-genotype combinations, available under the trade name Epclusa, contains sofosbuvir + velpatasvir[55]. 我们已经能够获得强大的市场善意,作为一个值得信赖的组织,为我们的客户提供SofihepSofosbuvir 400mg片剂。 We have been able to attain strong market goodwill as a trusted organization engaged in offering our clients Sovihep Sofosbuvir 400 mg Tablets. Sofosbuvir 被合理地容忍了:不良事件是常见的(81%),但严重的不良事件(17%)和治疗不连续性(8%)是不常见的。Sofosbuvir was reasonably well tolerated: adverse events were common(81%), but serious adverse events(17%) and treatment discontinuations(8%) were uncommon. DNDi展开STORM-C-1开放标签试验以评估候选药物ravidasvir与sofosbuvir 联用的疗效、安全性、耐药性和药物动力学。 DNDi conducted the STORM-C-1 open label trial to assess the efficacy, safety, tolerance and pharmacokinetics of the drug candidate ravidasvir combined with sofosbuvir . Sofosbuvir 是一种针对丙肝病毒的有效的直接抗病毒药物治疗,但是对潜在的肾脏毒性的担忧已经增加,尤其是在CKD患者身上。Sofosbuvir is a potent direct-acting antiviral therapy against HCV, but concerns about potential kidney toxicity have been raised, particularly in patients with CKD. 年4月7日,美国食品和药物管理局批准了Sovaldi(sofosbuvir )和Harvoni(ledipasvir和sofosbuvir )在12至17岁儿童中治疗丙型肝炎病毒(HCV)的补充申请。 The US Food and Drug Administration on April 7 approved supplemental applications for sofosbuvir and ledipasvir and sofosbuvir (Harvoni) to treat HCV in children ages 12 to 17.
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