Examples of using Fibrates in English and their translations into Danish
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Concomitant use of fibrates.
The use of fibrates alone is occasionally associated with myopathy.
The combined use of a statin and fibrates should generally be avoided.
Fibrates(eg, fenofibrate, gemfibrozil) because the risk of gallstones may be increased.
Medicines called statins or fibrates(to lower cholesterol) or ciclosporin.
As for others HMG-CoA reductase inhibitors, combination of pravastatin with fibrates is not recommended.
Gemfibrozil or other fibrates had been co- prescribed in 576(36.5%) of cases and clopidogrel in 246 15.6.
Adequate pharmacovigilance and pharmacokinetic data are not available for other fibrates.
Crestor with fibrates or niacin should be carefully weighed against the potential risks of such combinations.
Patients with previous history of photoallergy orphototoxic reaction during treatment with fibrates.
Medicines known as“ statins” and“ fibrates” used to treat elevated cholesterol and triglycerides have been associated with an increased risk of muscle breakdown rhabdomyolysis.
In clinical trials, the concomitant administration of Rapamune andHMG-CoA reductase inhibitors and/ or fibrates was well tolerated.
When cerivastatin was used concomitantly with fibrates(primarily gemfibrozil), there was a substantially higher reporting rate with increasing dose, depending on the reporting region.
Almost all subjects(95%) were receiving cardiovascular medications beta blockers, ACE inhibitors, angiotensin II antagonists, calcium channel blockers, nitrates, diuretics, aspirin,statins, fibrates.
The benefits of the combined use of simvastatin 10 mg daily with other fibrates(except fenofibrate), niacin or cyclosporine should be carefully weighed against the potential risks of these combinations.
It is not known whether the risk of myopathy during treatment with telbivudine is increased with concurrent administration of other medicinal products associated with myopathy e. g. statins, fibrates, or ciclosporin.
Liver tumours induced by gemfibrozil and other fibrates in small rodents are generally considered to be related to the extensive proliferation of peroxisomes in these species and, consequently, of minor clinical relevance.
The crude mortality rates were 8.3 per 1000 person- years for cerivastatin, 7.9 for atorvastatin, 10 for simvastatin, 10.8 for pravastatin and 11.9 for fluvastatin,as compared with 6.3 for fibrates, 4.2 in the untreated group.
In patients taking cyclosporine, gemfibrozil, other fibrates(except fenofibrate) or lipid-lowering doses(≥ 1 g/ day) of niacin concomitantly with< Zocord>, the dose of< Zocord> should not exceed 10 mg/day.
Almost all subjects(95%) were receiving cardiovascular medications beta blockers, ACE inhibitors, angiotensin II antagonists, calcium channel blockers, nitrates, diuretics, aspirin,statins, fibrates.
Gemfibrozil, fenofibrate, other fibrates and lipid lowering doses(> or equal to 1g/ day) of niacin(nicotinic acid) increase the risk of myopathy when given concomitantly with HMG-CoA reductase inhibitors, probably because they can produce myopathy when given alone.
The crude mortality rates were 11.9 per 1000 person- years for simvastatin, 12.2 for cerivastatin, 11.0 for atorvastatin, 10.8 for pravastatin, and 12.1 for fluvastatin,as compared with 7.9 for fibrates, 5.5 in the untreated group and 17.5 during the non- compliance period of patients treaded with hypolipidaemic agents at some point.
Moderate renal impairment(creatinine clearence< 60 ml/ min) hypothyroidism personal or family history of hereditary muscular disorders previous history of muscular toxicity with another HMG-CoA reductase inhibitor or fibrate alcohol abuse situations where an increase in plasma levels may occur Japanese and Chinese patients concomitant use of fibrates. .
Lack of interactions No interactions with amitriptyline, atorvastatin, biguanides,digoxin, fibrates, fluoxetine, losartan, phenytoin, phentermine, pravastatin, nifedipine Gastrointestinal Therapeutic System(GITS), nifedipine slow release, sibutramine or alcohol have been observed.
HMG-CoA reductase inhibitors, fibrates and ciclosporin.• Cubicin should not be administered to patients who are taking other medications associated with myopathy unless it is considered that the benefit to the patient outweighs the risk.• Patients should be reviewed regularly while on therapy for any signs or symptoms that might represent myopathy.• Any patient that develops unexplained muscle pain, tenderness, weakness or cramps should have CPK levels monitored every 2 days.
Medicines that may cause your blood sugar level to fall(hypoglycaemia) include:- all other medicines used to treat diabetes,- angiotensin converting enzyme(ACE)inhibitors, used to treat certain heart conditions or high blood pressure,- disopyramide(used to treat certain heart conditions),- fluoxetine(used to treat depression),- fibrates(used to lower high levels of blood lipids),- monoamine oxidase(MAO) inhibitors(used to treat depression),- pentoxifylline, propoxyphene, salicylates(such as aspirin, used to relieve pain and lower fever)- sulfonamide antibiotics.
The 40 mg dose is contraindicated with concomitant use of a fibrate see Section 4.3 Contraindications and Section 4.4 Special warnings and special precautions for use.
If a patient has previously experienced a muscle disorder on a fibrate or a statin, treatment with a different member of the class should only be initiated with caution.
Elderly(age> 70 years)• Renal impairment• Uncontrolled hypothyroidism• Personal or familial history of hereditary muscular disorders• Previous history of muscular toxicity with a statin or fibrate• Alcohol abuse.
For the statin-fibrate combination these data do not suggest any increased incidence of rhabdomyolysis(confirmed or unconfirmed)when any statin is used in combination with any fibrate.