Examples of using Patch clamp in English and their translations into Dutch
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Automated patch clamp for cells in vivo.
Ion channel recording can then be performed as in conventional patch clamping.
Automated patch clamp for cells in solution.
tissue, an alternative automated patch clamp technique can be used.
The patch clamp is a laboratory technique for studying currents in living cells.
An example of in vivo automated patch clamping protocol is provided by Kodandaramaiah, et al.
The patch clamp has been further revised with the invention of the gigaseal technique in 1980.
It is carried out similarly to cell attached patch clamping, but more suction is applied
The patch clamp technique was developed in the 1970s by Erwin Neher
can be used in patch clamp analysis, which is useful to characterise bacterial ion channels.
Automated patch clamp techniques, therefore, offer a means to screen hundreds of cells each day.
repeatability of this processes is improved compared to conventional patch clamping techniques where the operator would perform this manually.
High-throughput patch clamping is particularly pertinent in the field of drug discovery.
which mimic the hole of micropipette used in conventional patch clamping.
The steps performed in automated patch clamping are identical to those involved in manual patch clamping. .
improves execution of the patch clamping technique.
Contrastingly, automated patch clamping places cells on a multi-well plate
Some early techniques for single-molecule experiments include mass spectrometry or the use of the patch clamp technique for studying ion channels developed by Erwin Neher and Bert Sakmann.
however, patch clamp measurements have been applied to medical research- particularly to diseases that are attributed to ion channel malfunction.
Automated patch clamping accesses plates or chips using a"bottom-up" approach rather than"top-down" access to a single cell in conventional patch clamping.
In vitro responses seen in single channel patch clamp experiments using membrane patches from rodent cells expressing mutant CFTR forms do not necessarily correspond to in vivo pharmacodynamic response(e.g., sweat chloride) or clinical benefit.
Manual patch clamping requires considerable skill
In conventional patch clamping, the operator would need to decide whether the cell encountered is a target
Automated patch clamp techniques offer an advantage over conventional patch clamping as they remove the time constraint
Clamp. Patch is in place.
Top grade tempered glass door lock clamp patch fitting.